14. Endocrine Neoplasia
Published Online: 23 FEB 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Handbook of Clinical Pediatric Endocrinology, Second Edition
How to Cite
Brook, C. G. D. and Dattani, M. T. (2012) Endocrine Neoplasia, in Handbook of Clinical Pediatric Endocrinology, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781119968153.ch14
- Published Online: 23 FEB 2012
- Published Print: 13 APR 2012
Print ISBN: 9780470657881
Online ISBN: 9781119968153
- adrenal neoplasia;
- multiple endocrine neoplasia (MEN);
- ovarian tumors;
- tumors of the testes
This chapter describes the problem of endocrine neoplasia, which is rare in childhood. Its management is challenging and requires collaboration between the pediatric endocrinologist and oncologists, specialist surgeons, geneticists, clinical biochemists, pathologists, radiotherapists and anesthetists working as a team in collaboration with specialists in adult practice to facilitate seamless transition into adult medical services. Many children require lifelong endocrine therapies or surveillance for recurrent or associated disease. The rarity of these tumors is reflected in a lack of knowledge of the natural history of some of the conditions and a paucity of evidence informing management of advanced or relapsed disease. National and international collaborations seek to address these deficiencies by establishing disease registries and delivering rigorous clinical trials. Endocrine neoplasia often occurs in the context of genetic abnormalities, which may be associated with an increased lifetime risk of malignant disease in a number of endocrine or non-endocrine organs.