2. Hormones: Their Nature, Action and Measurement

  1. Charles G. D. Brook MA, MD, FRCP, FRCPCH1 and
  2. Mehul T. Dattani MD, FRCP, FRCPCH, DCH2,3

Published Online: 23 FEB 2012

DOI: 10.1002/9781119968153.ch2

Handbook of Clinical Pediatric Endocrinology, Second Edition

Handbook of Clinical Pediatric Endocrinology, Second Edition

How to Cite

Brook, C. G. D. and Dattani, M. T. (2012) Hormones: Their Nature, Action and Measurement, in Handbook of Clinical Pediatric Endocrinology, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781119968153.ch2

Author Information

  1. 1

    University College London, London, UK

  2. 2

    Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, UK

  3. 3

    Great Ormond Street Hospital for Children, London and University College London Hospitals, UK

Publication History

  1. Published Online: 23 FEB 2012
  2. Published Print: 13 APR 2012

ISBN Information

Print ISBN: 9780470657881

Online ISBN: 9781119968153

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Keywords:

  • endocrine rhythms;
  • endocrine tests;
  • hormone action;
  • hormone catabolism;
  • hormone measurement;
  • hormone recpetors;
  • hormone secretion;
  • hormone storage;
  • hormone synthesis;
  • hormone transport;
  • immunoassay;
  • peptide hormones;
  • reference ranges;
  • steroid hormones

Summary

This chapter explains what hormones are, how they work and how they are measured. Three types of hormone have been identified: those derived from tyrosine, peptide or protein hormones and steroid hormones, and three types of receptors – cell surface receptors, G-protein-coupled receptors, and intracellular receptors – transmit their action. Hormones are measured using immunoassays or immunometric assays and this chapter imparts knowledge of assays used in the laboratory and how to interpret hormone measurements. The chapter highlights how sensitivity, specificity, accuracy and precision affect clinical practice.