5. The Management of Growth Disorders

  1. Charles G. D. Brook MA, MD, FRCP, FRCPCH1 and
  2. Mehul T. Dattani MD, FRCP, FRCPCH, DCH2,3

Published Online: 23 FEB 2012

DOI: 10.1002/9781119968153.ch5

Handbook of Clinical Pediatric Endocrinology, Second Edition

Handbook of Clinical Pediatric Endocrinology, Second Edition

How to Cite

Brook, C. G. D. and Dattani, M. T. (2012) The Management of Growth Disorders, in Handbook of Clinical Pediatric Endocrinology, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781119968153.ch5

Author Information

  1. 1

    University College London, London, UK

  2. 2

    Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, UCL Institute of Child Health, UK

  3. 3

    Great Ormond Street Hospital for Children, London and University College London Hospitals, UK

Publication History

  1. Published Online: 23 FEB 2012
  2. Published Print: 13 APR 2012

ISBN Information

Print ISBN: 9780470657881

Online ISBN: 9781119968153



  • body measurement;
  • dysmorphic syndromes;
  • growth;
  • growth assessment;
  • growth hormone (GH);
  • height velocity;
  • insulin-like growth factor (IGF)-1;
  • Prader–Willi syndrome;
  • psychosocial short stature;
  • sex steroids;
  • short stature;
  • skeletal dysplasias;
  • tall stature;
  • thyroxine;
  • Turner syndrome


All endocrine orders affect growth. This chapter describes how to measure growth and how to detect and treat growth disorders. Postnatal growth is characterized by an infancy phase, regulated by nutrition, a childhood phase regulated by growth hormone and thyroxine and puberty growth regulated by sex steroids. Since normal growth is defined by a normal growth rate, regardless of height achieved, an understanding of how such rates vary in the three phases is key to determining further investigation. Since treatment follows diagnosis, nutrition, growth hormone and sex steroids all have parts to play. Growth hormone is also used in other situations which the chapter describes. A new area of clinical practice is the poor growth which follows the treatment of cancer. Tall stature can be a serious long-term problem as short stature is usually a short-term one; it is extremely important to rule out a diagnosis of precocious puberty and thyrotoxicosis, as well as gigantism.