10. Protein Interaction Networks and Their Statistical Analysis

  1. Michael P. H. Stumpf2,
  2. David J. Balding3 and
  3. Mark Girolami4
  1. Waqar Ali,
  2. Charlotte Deane and
  3. Gesine Reinert

Published Online: 12 SEP 2011

DOI: 10.1002/9781119970606.ch10

Handbook of Statistical Systems Biology

Handbook of Statistical Systems Biology

How to Cite

Ali, W., Deane, C. and Reinert, G. (2011) Protein Interaction Networks and Their Statistical Analysis, in Handbook of Statistical Systems Biology (eds M. P. H. Stumpf, D. J. Balding and M. Girolami), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119970606.ch10

Editor Information

  1. 2

    Division of Molecular Biosciences, Imperial College London, UK

  2. 3

    Institute of Genetics, University College London, UK

  3. 4

    Department of Statistical Science, University College London, UK

Author Information

  1. Department of Statistics, University of Oxford, UK

Publication History

  1. Published Online: 12 SEP 2011
  2. Published Print: 21 OCT 2011

ISBN Information

Print ISBN: 9780470710869

Online ISBN: 9781119970606

SEARCH

Keywords:

  • protein interaction networks;
  • post-genomic biology;
  • protein–protein interactions (PPI);
  • computationally predicted data-sets;
  • interactome concept;
  • functional annotation;
  • community detection;
  • cell dynamics

Summary

This chapter contains sections titled:

  • Introduction

  • Proteins and their interactions

  • Network analysis

  • Comparison of protein interaction networks

  • Evolution and the protein interaction network

  • Community detection in PPI networks

  • Predicting function using PPI networks

  • Predicting interactions using PPI networks

  • Current trends and future directions

  • References