25. Systems Biology of microRNAs

  1. Michael P. H. Stumpf3,
  2. David J. Balding4 and
  3. Mark Girolami5
  1. Doron Betel1 and
  2. Raya Khanin2

Published Online: 12 SEP 2011

DOI: 10.1002/9781119970606.ch25

Handbook of Statistical Systems Biology

Handbook of Statistical Systems Biology

How to Cite

Betel, D. and Khanin, R. (2011) Systems Biology of microRNAs, in Handbook of Statistical Systems Biology (eds M. P. H. Stumpf, D. J. Balding and M. Girolami), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119970606.ch25

Editor Information

  1. 3

    Division of Molecular Biosciences, Imperial College London, UK

  2. 4

    Institute of Genetics, University College London, UK

  3. 5

    Department of Statistical Science, University College London, UK

Author Information

  1. 1

    Institute of Computational Biomedicine, Weill Cornell Medical College, New York, USA

  2. 2

    Bioinformatics Core, Memorial Sloan-Kettering Cancer Center, New York, USA

Publication History

  1. Published Online: 12 SEP 2011
  2. Published Print: 21 OCT 2011

ISBN Information

Print ISBN: 9780470710869

Online ISBN: 9781119970606



  • systems biology of microRNAs;
  • microRNAs, short noncoding RNAs;
  • microRNA Systems Biology approaches;
  • cellular signals;
  • microRNA target prediction approaches;
  • mRNA expression;
  • microRNA kinetic modeling


This chapter contains sections titled:

  • Introduction

  • Current approaches in microRNA Systems Biology

  • Experimental findings and data that guide the developments of computational tools

  • Approaches to microRNA target predictions

  • Analysis of mRNA and microRNA expression data

  • Network approach for studying microRNA-mediated regulation

  • Kinetic modeling of microRNA regulation

  • Discussion

  • References