10. Ischemia

  1. Andrea Mozzarelli2,3 and
  2. Stefano Bettati2,3
  1. Hooman Mirzakhani and
  2. Ala Nozari

Published Online: 4 JUL 2011

DOI: 10.1002/9781119975427.ch10

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

How to Cite

Mirzakhani, H. and Nozari, A. (2011) Ischemia, in Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood (eds A. Mozzarelli and S. Bettati), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119975427.ch10

Editor Information

  1. 2

    Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy

  2. 3

    National Institute of Biostructures and Biosystems, Rome, Italy

Author Information

  1. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

Publication History

  1. Published Online: 4 JUL 2011
  2. Published Print: 12 AUG 2011

ISBN Information

Print ISBN: 9780470686683

Online ISBN: 9781119975427

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Keywords:

  • ischemia, blood flow perturbation to tissues - insufficient oxygen, energy substrates;
  • energy-rich substrate depletion - during ischemia, and parenchymal injury;
  • ischemic and reperfusion injuries - in myocardial infarction, or stroke;
  • calcium, intracellular ion - mediating multiple cellular functions;
  • ischemia-induced depletion of cellular energy - pathophysiological reactions;
  • cytosolic calcium role - in ischemic injury pathophysiology;
  • excitotoxicity, pathway - of irreversible cellular injury;
  • therapeutic potentials – techniques, mitigation of ischemic injury;
  • ROS role, in ischemic injury pathophysiology;
  • ischemia, rapid cellular energy depletion - injury, in pathophysiological network

Summary

This chapter contains sections titled:

  • Introduction

  • Pathophysiology

  • Therapeutic Potentials

  • Conclusion

  • References