11. Normobaric and Hyperbaric Oxygen Therapy for Ischemic Stroke and Other Neurological Conditions

  1. Andrea Mozzarelli3,4 and
  2. Stefano Bettati3,4
  1. Ari Moskowitz1,
  2. Yu-Feng Yvonne Chan1 and
  3. Aneesh B. Singhal2

Published Online: 4 JUL 2011

DOI: 10.1002/9781119975427.ch11

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

How to Cite

Moskowitz, A., Yvonne Chan, Y.-F. and Singhal, A. B. (2011) Normobaric and Hyperbaric Oxygen Therapy for Ischemic Stroke and Other Neurological Conditions, in Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood (eds A. Mozzarelli and S. Bettati), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119975427.ch11

Editor Information

  1. 3

    Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy

  2. 4

    National Institute of Biostructures and Biosystems, Rome, Italy

Author Information

  1. 1

    Department of Emergency Medicine, The Mount Sinai Medical Center, New York, NY, USA

  2. 2

    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA

Publication History

  1. Published Online: 4 JUL 2011
  2. Published Print: 12 AUG 2011

ISBN Information

Print ISBN: 9780470686683

Online ISBN: 9781119975427

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Keywords:

  • normobaric and hyperbaric oxygen therapy - ischemic stroke, other neurological conditions;
  • Centers for Disease Control (CDC) estimates - cerebrovascular diseases, cause of death in the United States;
  • oxygen therapy in acute ischemic stroke (AIS) - hyperoxia in cerebral ischemia;
  • hyperoxia, reducing cyclooxygenase-2 (COX-2) mRNA and MMP-9 - and intercellular adhesion molecule-1 (ICAM-1) levels;
  • hyperbaric oxygen therapy - and HBO use in organ ischemia;
  • preclinical testing, and therapeutic time window, dosage - in stroke subtypes;
  • normobaric oxygen therapy - 100% oxygen at atmospheric pressure, via face mask;
  • HBO use in deep-sea divers - decompression sickness (“the bends”) and arterial gas embolism;
  • NBO therapy, accessible - costing less, pleasant for patients, than the HBO

Summary

This chapter contains sections titled:

  • Introduction

  • Rationale of Oxygen Therapy in AIS

  • Hyperbaric Oxygen Therapy

  • Normobaric Oxygen Therapy

  • The Status of Supplemental Oxygen Delivery

  • Comparison of HBO and NBO in AIS

  • Safety Concerns

  • HBO and NBO in Other Conditions

  • Conclusion

  • References