12. Transfusion Therapy in β Thalassemia and Sickle Cell Disease

  1. Andrea Mozzarelli3,4 and
  2. Stefano Bettati3,4
  1. Carlo Brugnara1 and
  2. Lucia De Franceschi2

Published Online: 4 JUL 2011

DOI: 10.1002/9781119975427.ch12

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

How to Cite

Brugnara, C. and De Franceschi, L. (2011) Transfusion Therapy in β Thalassemia and Sickle Cell Disease, in Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood (eds A. Mozzarelli and S. Bettati), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119975427.ch12

Editor Information

  1. 3

    Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy

  2. 4

    National Institute of Biostructures and Biosystems, Rome, Italy

Author Information

  1. 1

    Departments of Pathology and Laboratory Medicine, Children's Hospital, Harvard Medical School, Boston, MA, USA

  2. 2

    Department of Medicine, University of Verona, Policlinico GB Rossi, Verona, Italy

Publication History

  1. Published Online: 4 JUL 2011
  2. Published Print: 12 AUG 2011

ISBN Information

Print ISBN: 9780470686683

Online ISBN: 9781119975427

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Keywords:

  • transfusion therapy in β thalassemia - and sickle cell disease;
  • hereditary disorders of production - hemoglobin (Hb) chains, monogenic inherited anemia;
  • gene mutations, pathophysiological events - and sickle cell disease (SCD) and β thalassemia;
  • β thalassemia and transfusion - genetic mutations, or deletions in β globin gene;
  • clinical management of β thalassemia major - and chronic transfusion;
  • sickle cell disease and transfusion - mutation in gene, for β globin;
  • acute ischemic stroke prevention, children - transcranial Doppler (TCD) blood-flow velocity determination;
  • SCD patients, transfusion complication - and chronic iron overload;
  • Deferasirox, recently approved oral iron chelator;
  • transfusion therapy, therapeutic modality - for β thalassemia and SCD

Summary

This chapter contains sections titled:

  • Introduction

  • β Thalassemia and Transfusion

  • Sickle Cell Disease and Transfusion

  • Iron Chelation Tools

  • Conclusion

  • References