18. Proteomic Investigations of Stored Red Blood Cells

  1. Andrea Mozzarelli2,3 and
  2. Stefano Bettati2,3
  1. Lello Zolla and
  2. Angelo D'Alessandro

Published Online: 4 JUL 2011

DOI: 10.1002/9781119975427.ch18

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

How to Cite

Zolla, L. and D'Alessandro, A. (2011) Proteomic Investigations of Stored Red Blood Cells, in Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood (eds A. Mozzarelli and S. Bettati), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119975427.ch18

Editor Information

  1. 2

    Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy

  2. 3

    National Institute of Biostructures and Biosystems, Rome, Italy

Author Information

  1. Department of Environmental Sciences, Tuscia University, Viterbo, Italy

Publication History

  1. Published Online: 4 JUL 2011
  2. Published Print: 12 AUG 2011

ISBN Information

Print ISBN: 9780470686683

Online ISBN: 9781119975427

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Keywords:

  • stored red blood cells - proteomic investigations;
  • red blood cells (RBCs) - most transfused blood component worldwide;
  • RBC ageing, metabolism in vivo - RBCs, role in gas transport;
  • humans, and circulating mature RBC - in bone marrow;
  • counteracting oxidative damage, anucleated RBC – protein synthesis nil;
  • RBC membrane system maintenance - and Hb function, energy generation;
  • RBC metabolism - and four main pathways;
  • RBC storage lesions - through proteomics;
  • a domino effect - for RBC storage lesions;
  • RBC biopreservation research - and “quality issue”

Summary

This chapter contains sections titled:

  • Introduction

  • RBC Ageing and Metabolism in vivo

  • RBC Storage Lesions Through Proteomics

  • Conclusion

  • References