19. Red Blood Cells from Stem Cells

  1. Andrea Mozzarelli3,4 and
  2. Stefano Bettati3,4
  1. Anna Rita Migliaccio1,
  2. Carolyn Whitsett1 and
  3. Giovanni Migliaccio2

Published Online: 4 JUL 2011

DOI: 10.1002/9781119975427.ch19

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

How to Cite

Migliaccio, A. R., Whitsett, C. and Migliaccio, G. (2011) Red Blood Cells from Stem Cells, in Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood (eds A. Mozzarelli and S. Bettati), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119975427.ch19

Editor Information

  1. 3

    Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy

  2. 4

    National Institute of Biostructures and Biosystems, Rome, Italy

Author Information

  1. 1

    Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, USA

  2. 2

    Department of Cell Biology and Neurosciences, Istituto Superiore Sanità, Rome, Italy

Publication History

  1. Published Online: 4 JUL 2011
  2. Published Print: 12 AUG 2011

ISBN Information

Print ISBN: 9780470686683

Online ISBN: 9781119975427

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Keywords:

  • red blood cells - from stem cells;
  • red cells, cellular elements of blood - oxygen delivery, tissues of body;
  • alternative sources of stem cells - properties of ex vivo-generated erythroid cells;
  • stem-cell sources for ex vivo generation - of erythroid cells, as transfusion product;
  • specific growth factors (GFs) - pluripotent hemopoietic stem cells (HSCs), and EPCs;
  • model for mechanism of action of GR and ESR - on erythroid maturation, transcription factor GATA1;
  • hypothetical ex vivo red cell production process anatomy;
  • biomarkers, monitoring EB expansion - in production;
  • safety concerns, for cell therapy - product exposure, xenogeneic substances;
  • ex vivo-expanded EBs for alloimmunized patients - alloimmunization, in multitransfused patients

Summary

This chapter contains sections titled:

  • Introduction

  • Stem-cell Sources for ex vivo Generation of Erythroid Cells as a Transfusion Product

  • Conditions that Favor ex vivo Erythroid Cell Expansion

  • A Clinical-grade Production Process for ex vivo Generation of Red-cell Transfusion Products

  • Time Line of the Clinical Application of ex vivo-generated Erythroid Cells

  • References