2. Hemoglobin Reactivity and Regulation

  1. Andrea Mozzarelli1,2 and
  2. Stefano Bettati1,2
  1. Stefano Bettati1,2 and
  2. Andrea Mozzarelli1,2

Published Online: 4 JUL 2011

DOI: 10.1002/9781119975427.ch2

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

How to Cite

Bettati, S. and Mozzarelli, A. (2011) Hemoglobin Reactivity and Regulation, in Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood (eds A. Mozzarelli and S. Bettati), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119975427.ch2

Editor Information

  1. 1

    Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy

  2. 2

    National Institute of Biostructures and Biosystems, Rome, Italy

Author Information

  1. 1

    Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy

  2. 2

    National Institute of Biostructures and Biosystems, Rome, Italy

Publication History

  1. Published Online: 4 JUL 2011
  2. Published Print: 12 AUG 2011

ISBN Information

Print ISBN: 9780470686683

Online ISBN: 9781119975427

SEARCH

Keywords:

  • oxygen, chemistry, biochemistry, physiology and toxicity - hemoglobin reactivity and regulation;
  • oxygen, key roles in living organisms - ATP in mitochondrial oxidative phosphorylation;
  • oxygen loading and transport - carbon dioxide released, oxygen loaded on Hb;
  • Hb function and regulation - and protein structural arrangement;
  • Hb, tetrameric protein - of two α and two β chains, tight αβ dimers;
  • relevant allosteric effector, DPG - binding to Hb central cavity;
  • Hb oxygen loading and unloading - and sigmoidal shape of OBC;
  • NO reactivity with Hb, nitric oxide (NO) binding to Hb - three distinct mechanisms;
  • Hb oxidation, and Hb autoxidizing - forming met-Hb and oxygen superoxide;
  • Hb function and regulation - and oxygen binding-associated events, not fully understood

Summary

This chapter contains sections titled:

  • Introduction

  • Oxygen Loading and Transport

  • NO Reactivity with Hb

  • Hb Oxidation

  • Nitrite Reactivity with Hb

  • Amino-acid Determinants of Hb Reactivity: Natural and Engineered Hbs

  • Conclusion

  • Acknowledgments

  • References