20. The Universal Red Blood Cell

  1. Andrea Mozzarelli2,3 and
  2. Stefano Bettati2,3
  1. Luca Ronda2 and
  2. Serena Faggiano1

Published Online: 4 JUL 2011

DOI: 10.1002/9781119975427.ch20

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

How to Cite

Ronda, L. and Faggiano, S. (2011) The Universal Red Blood Cell, in Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood (eds A. Mozzarelli and S. Bettati), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119975427.ch20

Editor Information

  1. 2

    Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy

  2. 3

    National Institute of Biostructures and Biosystems, Rome, Italy

Author Information

  1. 1

    MRC National Institute for Medical Research, London, UK

  2. 2

    Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy

Publication History

  1. Published Online: 4 JUL 2011
  2. Published Print: 12 AUG 2011

ISBN Information

Print ISBN: 9780470686683

Online ISBN: 9781119975427

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Keywords:

  • universal red blood cell;
  • blood transfusion, matching blood between donor - and transfused patient, a critical issue;
  • transfusion of ABO-incompatible blood - and fatal transfusion reactions;
  • effects of infusion of ABO-incompatible red blood cells (RBCs);
  • Rh blood-group system - highly polymorphic human blood-group system;
  • RBC surface antigens, exposed to mismatched blood - and antibody reactions;
  • ABO blood-group antigen biochemistry - enzymatic removal of A and B antigens;
  • RBC camouflage through PEGylation - immunocamouflaged RBCs;
  • effect of positively charged ε-amino group neutralization - PEGylation;
  • RBC camouflaging with PEG, alternative - masking non-ABO antigenic determinants

Summary

This chapter contains sections titled:

  • Introduction

  • Enzymatic Removal of A and B Antigens

  • RBC Camouflage Through PEGylation

  • Conclusion

  • References