21. Allosteric Effectors of Hemoglobin: Past, Present and Future

  1. Andrea Mozzarelli2,3 and
  2. Stefano Bettati2,3
  1. Martin K. Safo1 and
  2. Stefano Bruno2

Published Online: 4 JUL 2011

DOI: 10.1002/9781119975427.ch21

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

How to Cite

Safo, M. K. and Bruno, S. (2011) Allosteric Effectors of Hemoglobin: Past, Present and Future, in Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood (eds A. Mozzarelli and S. Bettati), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119975427.ch21

Editor Information

  1. 2

    Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy

  2. 3

    National Institute of Biostructures and Biosystems, Rome, Italy

Author Information

  1. 1

    Department of Medicinal Chemistry, School of Pharmacy and Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, VA, USA

  2. 2

    Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy

Publication History

  1. Published Online: 4 JUL 2011
  2. Published Print: 12 AUG 2011

ISBN Information

Print ISBN: 9780470686683

Online ISBN: 9781119975427

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Keywords:

  • allosteric effectors of hemoglobin - past, present and future;
  • hemoglobin (Hb), most studied - and understood example of allosteric protein;
  • allosteric equilibrium of Hb - modulated by effectors;
  • chemistry, mechanism of naturally occurring small molecules - altering Hb allosteric properties;
  • natural and synthetic allosteric effectors - organic phosphates, affecting oxygen affinity of Hb;
  • molecular mechanism of allosteric effector action - oxygen binding curve;
  • Hb allosteric effector studies - understanding concept of intrinsic activity;
  • hemoglobin allosteric effectors - clinical importance;
  • fully-oxygenated RBCs oxygen in larger vessels - lesser at arterioles, most at capillaries;
  • regulatory vasoconstriction - arterioles, leading to cell sickling

Summary

This chapter contains sections titled:

  • Introduction

  • Natural and Synthetic Allosteric Effectors

  • Molecular Mechanism of Action of Allosteric Effectors

  • The First Visualization of an Important Pharmacological Theory via Hb Allosteric Effector Binding

  • The Clinical Importance of Hemoglobin Allosteric Effectors

  • References