23. Oxygen Delivery by Natural and Artificial Oxygen Carriers

  1. Andrea Mozzarelli2,3 and
  2. Stefano Bettati2,3
  1. Enrico Bucci

Published Online: 4 JUL 2011

DOI: 10.1002/9781119975427.ch23

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

How to Cite

Bucci, E. (2011) Oxygen Delivery by Natural and Artificial Oxygen Carriers, in Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood (eds A. Mozzarelli and S. Bettati), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119975427.ch23

Editor Information

  1. 2

    Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy

  2. 3

    National Institute of Biostructures and Biosystems, Rome, Italy

Author Information

  1. University of Maryland Medical School, Department of Biochemistry and Molecular Biology, Baltimore, MD, USA

Publication History

  1. Published Online: 4 JUL 2011
  2. Published Print: 12 AUG 2011

ISBN Information

Print ISBN: 9780470686683

Online ISBN: 9781119975427

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Keywords:

  • oxygen delivery, natural and artificial oxygen carriers - oxygen, a toxic gas, for aerobic living;
  • oxygen carrier role, inactive - when bound to oxygen carrier;
  • role of natural cell-bound oxygen carriers - buffer capacity of carrier;
  • matching oxygen delivery rate - with oxygen consumption rate, and imbalance;
  • rebinding of oxygen by red cells at capillaries - part of reaction reversibility;
  • hematocrit, a critical parameter – buffer, compensating for imbalances;
  • oxygen transport - complex physiologic event;
  • HBOCs, clinical use - whether problematic in clinical settings;
  • HBOCs, administering - therapeutic calibrated amounts of oxygen

Summary

This chapter contains sections titled:

  • Introduction

  • The Role of Oxygen Carriers

  • The Role of Natural Cell-bound Oxygen Carriers

  • Matching the Rate of Oxygen Delivery with the Rate of Oxygen Consumption

  • The Role of Artificial Cell-free Oxygen Carriers

  • Other Parameters

  • Clinical Use?

  • Acknowledgments

  • References