27. Hemoglobin Vesicles as a Cellular-Type Hemoglobin-Based Oxygen Carrier

  1. Andrea Mozzarelli4,5 and
  2. Stefano Bettati4,5
  1. Hiromi Sakai1,2,
  2. Hirohisa Horinouchi3,
  3. Eishun Tsuchida2 and
  4. Koichi Kobayashi3

Published Online: 4 JUL 2011

DOI: 10.1002/9781119975427.ch27

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

How to Cite

Sakai, H., Horinouchi, H., Tsuchida, E. and Kobayashi, K. (2011) Hemoglobin Vesicles as a Cellular-Type Hemoglobin-Based Oxygen Carrier, in Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood (eds A. Mozzarelli and S. Bettati), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119975427.ch27

Editor Information

  1. 4

    Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy

  2. 5

    National Institute of Biostructures and Biosystems, Rome, Italy

Author Information

  1. 1

    Waseda Bioscience Research Institute in Singapore, Singapore, Republic of Singapore

  2. 2

    Research Institute for Science and Engineering, Waseda University, Shinjuku, Tokyo, Japan

  3. 3

    Department of Surgery, School of Medicine, Keio University, Shinjuku, Tokyo, Japan

Publication History

  1. Published Online: 4 JUL 2011
  2. Published Print: 12 AUG 2011

ISBN Information

Print ISBN: 9780470686683

Online ISBN: 9781119975427

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Keywords:

  • hemoglobin vesicles - a cellular-type hemoglobin-based oxygen carrier;
  • hemoglobin (Hb), most abundant protein in blood - essential protein;
  • chemically modified cell-free Hb-based oxygen carriers (HBOCs) - polymer-conjugated Hbs;
  • concept of Hb encapsulation - in liposomes;
  • HbVs, artificial oxygen carriers - encapsulating concentrated Hb solution;
  • preclinical studies of HbV - as transfusion alternative, and other therapeutics;
  • Hb encapsulation retards gas reactions – vasoconstriction, hypertension;
  • encapsulation of Hb in vesicles - retarding NO binding;
  • HBOCs as a carrier of O2 and CO - HBOCs as CO carriers;
  • CO, toxic gaseous molecule - cytoprotective effect depending on dose

Summary

This chapter contains sections titled:

  • Introduction

  • The Concept of Hb Encapsulation in Liposomes

  • Hb Encapsulation Retards Gas Reactions

  • HBOCs as a Carrier of not only O2 but also CO

  • Conclusion

  • Acknowledgments

  • References