3. The Major Physiological Control Mechanisms of Blood Flow and Oxygen Delivery

  1. Andrea Mozzarelli2,3 and
  2. Stefano Bettati2,3
  1. Raymond C. Koehler

Published Online: 4 JUL 2011

DOI: 10.1002/9781119975427.ch3

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

How to Cite

Koehler, R. C. (2011) The Major Physiological Control Mechanisms of Blood Flow and Oxygen Delivery, in Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood (eds A. Mozzarelli and S. Bettati), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119975427.ch3

Editor Information

  1. 2

    Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy

  2. 3

    National Institute of Biostructures and Biosystems, Rome, Italy

Author Information

  1. Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD, USA

Publication History

  1. Published Online: 4 JUL 2011
  2. Published Print: 12 AUG 2011

ISBN Information

Print ISBN: 9780470686683

Online ISBN: 9781119975427

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Keywords:

  • major physiological control mechanisms - of blood flow and oxygen delivery;
  • perfusion of microcirculation - and arterio-venous pressure gradient;
  • blood flow autoregulation – and perfusion pressure changes;
  • primary mechanism of myogenic response - stretch-activated channel stimulation;
  • blood flow autoregulation - fundamental characteristic of vasoregulation;
  • blood flow metabolic regulation - in tissues;
  • bulk O2 transport to microcirculation - product of arterial O2 content, and blood flow;
  • vasomotor tone, endothelial control - in vascular smooth muscle regulation;
  • carbon monoxide hypoxia - decrease in CaO2 and decrease in p50;
  • vascular smooth muscle - and intrinsic myogenic tone, with transmural pressure

Summary

This chapter contains sections titled:

  • Introduction

  • Autoregulation of Blood Flow to Changes in Perfusion Pressure

  • Metabolic Regulation of Blood Flow

  • O2 Transport

  • O2 Delivery

  • Endothelial Control of Vasomotor Tone

  • Effect of Cell-free Hb on Endothelial Function

  • Hypoxic Hypoxia

  • Carbon Monoxide Hypoxia

  • Anemia

  • Conclusion

  • References