5. The Role of Reactive Oxygen and Nitrogen Species in Ischemia/Reperfusion Injury

  1. Andrea Mozzarelli2,3 and
  2. Stefano Bettati2,3
  1. Ester Spagnolli and
  2. Warren M. Zapol

Published Online: 4 JUL 2011

DOI: 10.1002/9781119975427.ch5

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood

How to Cite

Spagnolli, E. and Zapol, W. M. (2011) The Role of Reactive Oxygen and Nitrogen Species in Ischemia/Reperfusion Injury, in Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood (eds A. Mozzarelli and S. Bettati), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119975427.ch5

Editor Information

  1. 2

    Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy

  2. 3

    National Institute of Biostructures and Biosystems, Rome, Italy

Author Information

  1. Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

Publication History

  1. Published Online: 4 JUL 2011
  2. Published Print: 12 AUG 2011

ISBN Information

Print ISBN: 9780470686683

Online ISBN: 9781119975427

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Keywords:

  • role of reactive oxygen - and nitrogen species in ischemia/reperfusion (I/R) injury;
  • arterial blood flow, prolonged interruption - to organ or tissue, causing ischemia;
  • ROS and RNS in biological environments - mechanisms of reperfusion injury;
  • redox system, grouping biological reactions - pro-oxidant and antioxidant effects;
  • oxygenated blood continuous delivery - to vital organs, and tissue survival;
  • ischemia/reperfusion injury - arterial blood flow interruption;
  • dual role of ROS and RNS in I/R injury - reperfusion, burst of ROS and intracellular organelle damage;
  • protective role of ROS and antioxidants;
  • I/R injury, jeopardizing vital organ function - in acute myocardial infarction (AMI), organ transplantation;
  • I/R damage, and mechanisms responsible - novel protective strategies

Summary

This chapter contains sections titled:

  • Introduction

  • Redox System and Free Radicals in Biological Systems

  • Pathophysiology of Ischemia/Reperfusion Injury

  • Protection Against I/R Injury

  • Conclusion

  • Acknowledgments

  • References