14. Early Tolerization to Minimize Inhibitors in PUPs with Hemophilia A

  1. Emérito-Carlos Rodríguez-Merchán MD, PHD2,3 and
  2. Leonard A. Valentino MD4
  1. Günter Auerswald MD and
  2. Karin Kurnik MD

Published Online: 12 MAY 2011

DOI: 10.1002/9781119979401.ch14

Current and Future Issues in Hemophilia Care

Current and Future Issues in Hemophilia Care

How to Cite

Auerswald, G. and Kurnik, K. (2011) Early Tolerization to Minimize Inhibitors in PUPs with Hemophilia A, in Current and Future Issues in Hemophilia Care (eds E.-C. Rodríguez-Merchán and L. A. Valentino), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781119979401.ch14

Editor Information

  1. 2

    Department of Orthopedic Surgery and Hemophilia Unit, La Paz University Hospital, Spain

  2. 3

    School of Medicine, Autonomous University, Madrid, Spain

  3. 4

    Hemophilia and Thrombophilia Center, Rush University Medical Center, Chicago, IL, USA

Author Information

  1. Klinikum Bremen-Mitte, Ambulanz für Thrombose und Hämostasestörungen, Prof.-Hess Kinderklinik, Bremen, Germany

Publication History

  1. Published Online: 12 MAY 2011
  2. Published Print: 13 MAY 2011

ISBN Information

Print ISBN: 9780470670576

Online ISBN: 9781119979401

SEARCH

Keywords:

  • hemophilia;
  • inhibitors;
  • PUPs;
  • early tolerization;
  • minimization

Summary

Early start of prophylaxis associated with minimizing immunological danger signals during the first 20 exposure days with FVIII should be considered for future therapy of patients with severe hemophilia A to reduce the risk of inhibitor formation. Once the patients have developed tolerance to FVIII, usually after about 20 to 50 EDs on the low dose regimen, and venous access permitted, prophylaxis might be changed to the normal three times weekly regimen for optimal joint protection.