31. Laboratory Assays to Predict Response to Bypassing Agents

  1. Emérito-Carlos Rodríguez-Merchán MD, PHD4,5 and
  2. Leonard A. Valentino MD6
  1. Benny Sørensen MD, PhD1,2 and
  2. Claude Negrier MD, PhD3

Published Online: 12 MAY 2011

DOI: 10.1002/9781119979401.ch31

Current and Future Issues in Hemophilia Care

Current and Future Issues in Hemophilia Care

How to Cite

Sørensen, B. and Negrier, C. (2011) Laboratory Assays to Predict Response to Bypassing Agents, in Current and Future Issues in Hemophilia Care (eds E.-C. Rodríguez-Merchán and L. A. Valentino), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781119979401.ch31

Editor Information

  1. 4

    Department of Orthopedic Surgery and Hemophilia Unit, La Paz University Hospital, Spain

  2. 5

    School of Medicine, Autonomous University, Madrid, Spain

  3. 6

    Hemophilia and Thrombophilia Center, Rush University Medical Center, Chicago, IL, USA

Author Information

  1. 1

    Aarhus University, Denmark, UK

  2. 2

    Haemostasis Research Unit Centre for Haemophilia and Thrombosis Guy's and St Thomas' NHS Foundation Trust London, UK

  3. 3

    Hematology Division, Edouard Herriot University Hospital, Lyon, France

Publication History

  1. Published Online: 12 MAY 2011
  2. Published Print: 13 MAY 2011

ISBN Information

Print ISBN: 9780470670576

Online ISBN: 9781119979401

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Keywords:

  • Laboratory Assays to Predict Response to Bypassing Agents;
  • activated partial thromboplastin time (APTT);
  • endogenous thrombin potential (ETP);
  • tissue factor pathway inhibitor (TFPI);
  • platelet rich plasma (PRP)

Summary

This chapter contains sections titled:

  • Introduction

  • The need for theranostic guidance in management of hemophilia patients with inhibitors

  • Calibrated automated thrombin generation

  • Translation of laboratory results to clinical practice

  • Prediction of response to bypassing agents

  • Individualized dose tailoring of bypassing agents during orthopedic surgery

  • Whole blood thromboelastometry

  • Complementary additional information on overall hemostatic capacity

  • Conclusions

  • References