4. When Should we Switch from On-Demand to Prophylaxis Regimen?
- Emérito-Carlos Rodríguez-Merchán MD, PHD2,3 and
- Leonard A. Valentino MD4
Published Online: 12 MAY 2011
Copyright © 2011 John Wiley & Sons Ltd
Current and Future Issues in Hemophilia Care
How to Cite
Aznar, J. A., Moret, A., Abad-Franch, L., Cid, A. R., Haya, S. and Querol, F. (2011) When Should we Switch from On-Demand to Prophylaxis Regimen?, in Current and Future Issues in Hemophilia Care (eds E.-C. Rodríguez-Merchán and L. A. Valentino), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781119979401.ch4
Department of Orthopedic Surgery and Hemophilia Unit, La Paz University Hospital, Spain
School of Medicine, Autonomous University, Madrid, Spain
Hemophilia and Thrombophilia Center, Rush University Medical Center, Chicago, IL, USA
- Published Online: 12 MAY 2011
- Published Print: 13 MAY 2011
Print ISBN: 9780470670576
Online ISBN: 9781119979401
Prophylaxis is the regular administration of factor concentrates in order to prevent spontaneous hemorrhages and is the recommended therapy for patients with severe hemophilia. There is a global consensus about starting prophylaxis early (before the development of joint damage), continuing prophylaxis in adolescents and possibly maintaining the prophylaxis into adult age. Maintaining prophylaxis in adults that started it early must be individualized. Starting secondary prophylaxis in adolescents and adults that already have joint damage reduces bleedings and can provide those patients some of the same benefits observed in pediatric patients. The results of the published works are encouraging even yet there is no evidence which shows the efficacy of prophylaxis in these groups.