3a. Commentaries

  1. Dan J. Stein MD, PhD3,4,
  2. Matthew J. Friedman MD5,6 and
  3. Carlos Blanco MD, PhD7
  1. Brian H. Harvey1 and
  2. Eric Vermetten2

Published Online: 15 JUL 2011

DOI: 10.1002/9781119998471.ch3a

Post-Traumatic Stress Disorder

Post-Traumatic Stress Disorder

How to Cite

Harvey, B. H. and Vermetten, E. (2011) Commentaries, in Post-Traumatic Stress Disorder (eds D. J. Stein, M. J. Friedman and C. Blanco), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119998471.ch3a

Editor Information

  1. 3

    Department of Psychiatry, University of Cape Town, Cape Town, South Africa

  2. 4

    Mount Sinai School of Medicine, New York, NY, USA

  3. 5

    Department of Psychiatry and of Pharmacology & Toxicology, Dartmouth Medical School, USA

  4. 6

    National Center for Posttraumatic Stress Disorder, US Department of Veterans Affairs, Hanover, NH, USA

  5. 7

    Department of Psychiatry, Columbia University, New York, NY, USA

Author Information

  1. 1

    Division of Pharmacology, Unit for Drug Research and Development, School of Pharmacy, North-West University (Potchefstroom campus), Potchefstroom, South Africa

  2. 2

    Military Mental Health, Department of Defence; Department of Psychiatry, University Medical Center, Utrecht, The Netherlands

Publication History

  1. Published Online: 15 JUL 2011
  2. Published Print: 29 JUL 2011

Book Series:

  1. World Psychiatric Association Evidence and Experience in Psychiatry Series

Book Series Editors:

  1. Helen Herrman

Series Editor Information

  1. WPA Secretary for Publications, University of Melbourne, Australia

ISBN Information

Print ISBN: 9780470688977

Online ISBN: 9781119998471



  • translational theory-driven hypotheses and testing - understanding of PTSD;
  • Hans Selye, explaining importance - of stress response in health and disease;
  • stress-related mental illnesses - and genetic predisposition, nature of stressors;
  • field of PTSD - fuelled with intriguing findings and paradoxes;
  • fear conditioning to emotion regulation - fear and other emotional symptoms, in PTSD;
  • increased glucocorticoid receptor binding capacity - peripheral blood mononuclear cells, vulnerability factor for PTSD symptoms;
  • combating stress on amygdala coupling - insula and dorsal anterior cingulate cortex, perceived threat;
  • stress, psychophysiological and neural responses - underlying PTSD, changing with exposure to stressors


This chapter contains sections titled:

  • Translational Theory-Driven Hypotheses and Testing Are Enhancing Our Understanding of PTSD and its Treatment

  • Precipitating and design approaches to PTSD