11. Adverse Effects of Antiepileptic Drugs

  1. James W. Wheless
  1. James W. Wheless

Published Online: 1 NOV 2012

DOI: 10.1002/9781119998600.ch11

Epilepsy in Children and Adolescents

Epilepsy in Children and Adolescents

How to Cite

Wheless, J. W. (2012) Adverse Effects of Antiepileptic Drugs, in Epilepsy in Children and Adolescents (ed J. W. Wheless), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119998600.ch11

Editor Information

  1. Department of Pediatric Neurology, University of Tennessee Health Science Center, Le Bonheur Comprehensive Epilepsy Program and Neuroscience Institute, Le Bonheur Children's Hospital, Memphis, TN, USA

Author Information

  1. Department of Pediatric Neurology, University of Tennessee Health Science Center, Le Bonheur Comprehensive Epilepsy Program and Neuroscience Institute, Le Bonheur Children's Hospital, Memphis, TN, USA

Publication History

  1. Published Online: 1 NOV 2012
  2. Published Print: 23 NOV 2012

ISBN Information

Print ISBN: 9780470741238

Online ISBN: 9781119998600

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Keywords:

  • side effect;
  • adverse reaction;
  • neurotoxicity;
  • antiepileptic drug;
  • idiosyncratic;
  • idiopathic;
  • at-risk profile

Summary

Treatment of children with epilepsy strives for complete seizure control without medication side effects. However, antiepileptic drugs can cause non-specific dose-related responses, unique effects specific to a given drug, or rare but potentially dangerous idiosyncratic reactions. This chapter examines the range of potential adverse reactions when using medication to treat epilepsy, and details the main reported side effects for each of the major antiepileptic drugs. Also, the strategy of minimizing the risk of serious adverse effects by compiling at-risk clinic profiles from reports of idiopathic drug reactions is introduced.