2. Glucocorticoids: Pharmacology and Mechanisms

  1. Jan Lötvall
  1. Peter J. Barnes

Published Online: 29 FEB 2012

DOI: 10.1002/9781119998624.ch2

Advances in Combination Therapy for Asthma and COPD

Advances in Combination Therapy for Asthma and COPD

How to Cite

Barnes, P. J. (2012) Glucocorticoids: Pharmacology and Mechanisms, in Advances in Combination Therapy for Asthma and COPD (ed J. Lötvall), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119998624.ch2

Editor Information

  1. Krefting Research Centre, University of Gothenburg, Göteborg, Sweden

Author Information

  1. Section of Airway Disease, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK

Publication History

  1. Published Online: 29 FEB 2012
  2. Published Print: 3 FEB 2012

ISBN Information

Print ISBN: 9780470727027

Online ISBN: 9781119998624



  • glucocorticoid, pharmacology;
  • glucocorticoids, and inflammatory diseases;
  • molecular basis of inflammation;
  • cellular effects;
  • glucocorticoid receptors;
  • gene expression regulation;
  • gene transcription activation;
  • inflammatory gene suppression;
  • asthma, and glucocorticoid effectiveness;
  • glucocorticoid, ineffectiveness in COPD


This chapter contains sections titled:

  • Introduction

  • Chemical structures

  • The molecular basis of inflammation

  • Cellular effects of glucocorticoids

  • Glucocorticoid receptors

  • Glucocorticoid activation of gene transcription

  • Suppression of inflammatory genes

  • Steroid resistance

  • Interaction with β2-adrenergic receptors

  • Conclusions

  • References