10. Anatomical and Neurochemical Evidence of Neurotoxic Changes in Psychostimulant Abuse and Dependence

  1. Bryon Adinoff5,6 and
  2. Elliot A. Stein7
  1. Young Hoon Sung1,2 and
  2. Perry F. Renshaw1,2,3,4

Published Online: 2 NOV 2011

DOI: 10.1002/9781119998938.ch10

Neuroimaging in Addiction

Neuroimaging in Addiction

How to Cite

Sung, Y. H. and Renshaw, P. F. (2011) Anatomical and Neurochemical Evidence of Neurotoxic Changes in Psychostimulant Abuse and Dependence, in Neuroimaging in Addiction (eds B. Adinoff and E. A. Stein), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119998938.ch10

Editor Information

  1. 5

    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA

  2. 6

    VA North Texas Health Care System, Dallas, TX, USA

  3. 7

    National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA

Author Information

  1. 1

    The Brain Institute, Salt Lake City, UT, USA

  2. 2

    Depart. of Psychiatry, Salt Lake City, UT, USA

  3. 3

    USTAR, Salt Lake City, UT, UT, USA

  4. 4

    4VISN 19 MIRECC, Salt Lake City, UT, USA

Publication History

  1. Published Online: 2 NOV 2011
  2. Published Print: 9 NOV 2011

ISBN Information

Print ISBN: 9780470660140

Online ISBN: 9781119998938

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Keywords:

  • psychostimulant abuse, dependence;
  • substance dependence;
  • neuroimaging techniques;
  • amphetamine dependence;
  • MDMA, recreational drug;
  • stimulant drug use, relapsing;
  • brain damage in MDMA abuse;
  • cognitive deficits, compulsive drug-seeking;
  • diffusion tensor imaging (DTI) in neuroimaging;
  • MR neuroimaging

Summary

This chapter contains sections titled:

  • Introduction

  • Characteristics of Psychostimulants

  • Quantitative MR Morphology Changes Associated with Psychostimulant Dependence

  • Gross Anatomic Changes in Brain Structures and Subtle Neurotoxicity

  • Relationship between Errant Neuromodulation by Drug Abuse and Cognitive Abnormalities

  • Neurochemical Alterations and Psychostimulant Dependence

  • Abnormal White Matter Integrity in Psychostimulant Dependence

  • Alcohol and Opiate Addiction

  • Conclusion

  • References