9. Neural Mechanisms of Stress and Addiction

  1. Bryon Adinoff3,4 and
  2. Elliot A. Stein5
  1. Dongju Seo1 and
  2. Rajita Sinha2

Published Online: 2 NOV 2011

DOI: 10.1002/9781119998938.ch9

Neuroimaging in Addiction

Neuroimaging in Addiction

How to Cite

Seo, D. and Sinha, R. (2011) Neural Mechanisms of Stress and Addiction, in Neuroimaging in Addiction (eds B. Adinoff and E. A. Stein), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781119998938.ch9

Editor Information

  1. 3

    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA

  2. 4

    VA North Texas Health Care System, Dallas, TX, USA

  3. 5

    National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA

Author Information

  1. 1

    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA

  2. 2

    Department of Psychiatry and Child Study, Yale University School of Medicine, New Haven, CT, USA

Publication History

  1. Published Online: 2 NOV 2011
  2. Published Print: 9 NOV 2011

ISBN Information

Print ISBN: 9780470660140

Online ISBN: 9781119998938



  • stress and addiction, neural mechanisms;
  • stress, state of disrupted homeostasis;
  • neural mechanisms of stress;
  • cortico-striatal-limbic circuit;
  • stress and reward regulation;
  • medial PFC, emotional control;
  • amygdala and nucleus accumbens;
  • stress and addiction;
  • vulnerabilities to drug;
  • gene, stress, drug intake interplay


This chapter contains sections titled:

  • Stress and Addiction

  • Neural Circuits of Stress Regulation

  • Dysfunction in the Neural Circuits Underlying Stress and Addiction

  • Interplay of Gene, Stress, and Drug Intake

  • Acknowledgments

  • References