Chapter 21. The Skin in Systemic Disease

  1. Richard P. J. B. Weller MD, FRCP (Edin) Senior Lecturer1,
  2. John A. A. Hunter OBE, BA, MD, FRCP (Edin) Professor Emeritus of Dermatology2,
  3. John A. Savin MA, MD, ChB, FRCP, DIH Former Consultant Dermatologist3 and
  4. Mark V. Dahl BA, MD Professor of Dermatology former Chairman Professor Emeritus4,5

Published Online: 14 JAN 2009

DOI: 10.1002/9781444300086.ch21

Clinical Dermatology, Fourth Edition

Clinical Dermatology, Fourth Edition

How to Cite

Weller, R. P. J. B., Hunter, J. A. A., Savin, J. A. and Dahl, M. V. (2008) The Skin in Systemic Disease, in Clinical Dermatology, Fourth Edition, Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444300086.ch21

Author Information

  1. 1

    Department of Dermatology, University of Edinburgh, Edinburgh, UK

  2. 2

    University of Edinburgh, Edinburgh, UK

  3. 3

    The Royal Infirmary, Edinburgh, UK

  4. 4

    College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ, USA

  5. 5

    University of Minnesota Medical School, Minneapolis, MN, USA

Publication History

  1. Published Online: 14 JAN 2009
  2. Published Print: 7 MAR 2008

ISBN Information

Print ISBN: 9781405146630

Online ISBN: 9781444300086



  • skin in systemic disease;
  • acanthosis nigricans;
  • skin and diabetes mellitus;
  • necrobiosis lipoidica - shiny yellowish patch with marked telangiectasia;
  • diabetic cheiropathy – the prayer sign;
  • skin in renal disease;
  • graft-vs.-host disease;
  • cutaneous hepatic porphyria (porphyria cutanea tarda);
  • generalized pruritus;
  • hypopigmentation and phenylketonuria - rare metabolic cause


This chapter contains sections titled:

  • The skin and internal malignancy

  • The skin and diabetes mellitus

  • The skin in sarcoidosis

  • The skin in liver disease

  • The skin in renal disease

  • Graft-vs.-host disease

  • Malabsorption and malnutrition

  • The porphyrias

  • Some metabolic disorders

  • Generalized pruritus

  • Pyoderma gangrenosum

  • Further reading