Chapter 10. Neurohormonal and Hormonal Control of Exocrine Pancreatic Secretion

  1. Hans G. Beger MD, FACS(Hon) Founding Editor Emeritus Professor of Surgery2,
  2. Andrew L. Warshaw MD Surgeon-in-Chief Chairman3,4,
  3. Markus W. Büchler MD Chairman Head Professor of Surgery5,
  4. Richard A. Kozarek MD Director6,
  5. Markus M. Lerch MD, FRCP Professor Chair7,
  6. John P. Neoptolemos MA, MB, BChir, MD, FRCS, FMedSci Head Professor of Surgery8,9,10,
  7. Keiko Shiratori MD Chair Professor11,
  8. David C. Whitcomb MD, PhD Professor of Medicine Chief12 and
  9. Bettina M. Rau MD Coordinating Editor Associate Professor of Surgery13
  1. Chung Owyang MD Professor of Surgery

Published Online: 4 FEB 2009

DOI: 10.1002/9781444300123.ch10

The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery, Second Edition

The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery, Second Edition

How to Cite

Owyang, C. (2009) Neurohormonal and Hormonal Control of Exocrine Pancreatic Secretion, in The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery, Second Edition (eds H. G. Beger, A. L. Warshaw, M. W. Büchler, R. A. Kozarek, M. M. Lerch, J. P. Neoptolemos, K. Shiratori, D. C. Whitcomb and B. M. Rau), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444300123.ch10

Editor Information

  1. 2

    c/o Universitätsklinikum Ulm, University of Ulm, Germany

  2. 3

    Department of Surgery, Massachusetts General Hospital, Boston, MA, USA

  3. 4

    W. Gerald Austen Professor of Surgery, Harvard Medical School, Boston, MA, USA

  4. 5

    Department of General and Visceral Surgery, University of Heidelberg, Germany

  5. 6

    Digestive Disease Institute, Virginia Mason Medical Center, Seattle, WA, USA

  6. 7

    Department of Gastroenterology, Endocrinology and Nutrition, Ernst-Moritz-Arndt University, Greifswald, Germany

  7. 8

    The Owen and Ellen Evans Chair of Cancer Studies, University of Liverpool, UK

  8. 9

    Division of Surgery and Oncology, University of Liverpool, UK

  9. 10

    School of Cancer Studies, University of Liverpool, UK

  10. 11

    Department of Gastroenterology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan

  11. 12

    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, PA, USA

  12. 13

    Department of General, Thoracic, Vascular and Transplantation Surgery, University of Rostock, Germany

Author Information

  1. A. Alfred Taubman Health Care Center, Ann Arbor, MI, USA

Publication History

  1. Published Online: 4 FEB 2009
  2. Published Print: 11 APR 2008

ISBN Information

Print ISBN: 9781405146647

Online ISBN: 9781444300123

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Keywords:

  • neurohormonal and exocrine pancreatic hormonal control;
  • vagal high-affinity CCK receptors;
  • high- and low-affinity CCK-A receptors;
  • vagal CCK and 5HT receptor synergistic interaction;
  • pancreatic secretion and hypothalamic regulation;
  • hypothalamus–brainstem circuitry;
  • vagal efferent signaling to pancreas;
  • calcitonin gene-related peptide (CGRP);
  • Ghrelin - novel acylated peptide

Summary

This chapter contains sections titled:

  • Introduction

  • Mechanism of actions of CCK on pancreatic secretion

  • Mechanisms of non-CCK-dependent factors on pancreatic secretion

  • Actions of secretin on pancreatic fluid and bicarbonate secretion

  • Hypothalamic regulation of pancreatic secretion

  • Peripheral hormones modulate pancreatic secretion at a central vagal site(s)

  • References