Chapter 20. Histopathology of Acute Pancreatitis

  1. Hans G. Beger MD, FACS(Hon) Founding Editor Emeritus Professor of Surgery2,
  2. Andrew L. Warshaw MD Surgeon-in-Chief Chairman3,4,
  3. Markus W. Büchler MD Chairman Head Professor of Surgery5,
  4. Richard A. Kozarek MD Director6,
  5. Markus M. Lerch MD, FRCP Professor Chair7,
  6. John P. Neoptolemos MA, MB, BChir, MD, FRCS, FMedSci Head Professor of Surgery8,9,10,
  7. Keiko Shiratori MD Chair Professor11,
  8. David C. Whitcomb MD, PhD Professor of Medicine Chief12 and
  9. Bettina M. Rau MD Coordinating Editor Associate Professor of Surgery13
  1. Günter Klöppel MD Professor of Pathology Director

Published Online: 4 FEB 2009

DOI: 10.1002/9781444300123.ch20

The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery, Second Edition

The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery, Second Edition

How to Cite

Klöppel, G. (2008) Histopathology of Acute Pancreatitis, in The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery, Second Edition (eds H. G. Beger, A. L. Warshaw, M. W. Büchler, R. A. Kozarek, M. M. Lerch, J. P. Neoptolemos, K. Shiratori, D. C. Whitcomb and B. M. Rau), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444300123.ch20

Editor Information

  1. 2

    c/o Universitätsklinikum Ulm, University of Ulm, Germany

  2. 3

    Department of Surgery, Massachusetts General Hospital, Boston, MA, USA

  3. 4

    W. Gerald Austen Professor of Surgery, Harvard Medical School, Boston, MA, USA

  4. 5

    Department of General and Visceral Surgery, University of Heidelberg, Germany

  5. 6

    Digestive Disease Institute, Virginia Mason Medical Center, Seattle, WA, USA

  6. 7

    Department of Gastroenterology, Endocrinology and Nutrition, Ernst-Moritz-Arndt University, Greifswald, Germany

  7. 8

    The Owen and Ellen Evans Chair of Cancer Studies, University of Liverpool, UK

  8. 9

    Division of Surgery and Oncology, University of Liverpool, UK

  9. 10

    School of Cancer Studies, University of Liverpool, UK

  10. 11

    Department of Gastroenterology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan

  11. 12

    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, PA, USA

  12. 13

    Department of General, Thoracic, Vascular and Transplantation Surgery, University of Rostock, Germany

Author Information

  1. Department of Pathology, University of Kiel, Germany

Publication History

  1. Published Online: 4 FEB 2009
  2. Published Print: 11 APR 2008

ISBN Information

Print ISBN: 9781405146647

Online ISBN: 9781444300123

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Keywords:

  • acute pancreatitis histopathology;
  • acute pancreatitis and type 3 necrosis pattern;
  • etiologic factors and histopathology;
  • unsolved questions in acute pancreatitis;
  • acinar cell damage hypothesis and acinar cell function complex disturbance;
  • type 3 damage pattern and primary acinar cell necrosis;
  • necrosis pattern characterizes classical type of acute pancreatitis;
  • trypsinogen uncontrolled autoactivation and acute pancreatitis type 2 necrosis pattern

Summary

This chapter contains sections titled:

  • Introduction

  • Definition

  • Atlanta classification and histopathologic changes

  • Histopathologic patterns of tissue necrosis

  • Acute pancreatitis with type 1 necrosis pattern

  • Acute pancreatitis with type 2 necrosis pattern

  • Acute pancreatitis with type 3 necrosis pattern

  • Histopathology in relation to etiologic factors

  • Histopathology in relation to pathogenesis

  • Unsolved questions

  • References