Chapter 38. Fibrogenesis of the Pancreas: The Role of Stellate Cells

  1. Hans G. Beger MD, FACS(Hon) Founding Editor Emeritus Professor of Surgery3,
  2. Andrew L. Warshaw MD Surgeon-in-Chief Chairman4,5,
  3. Markus W. Büchler MD Chairman Head Professor of Surgery6,
  4. Richard A. Kozarek MD Director7,
  5. Markus M. Lerch MD, FRCP Professor Chair8,
  6. John P. Neoptolemos MA, MB, BChir, MD, FRCS, FMedSci Head Professor of Surgery9,10,11,
  7. Keiko Shiratori MD Chair Professor12,
  8. David C. Whitcomb MD, PhD Professor of Medicine Chief13 and
  9. Bettina M. Rau MD Coordinating Editor Associate Professor of Surgery14
  1. Max G. Bachem MD Director1,
  2. Shaoxia Zhou,
  3. Wilhelm Schneiderhan and
  4. Marco Siech MD2

Published Online: 4 FEB 2009

DOI: 10.1002/9781444300123.ch38

The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery, Second Edition

The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery, Second Edition

How to Cite

Bachem, M. G., Zhou, S., Schneiderhan, W. and Siech, M. (2008) Fibrogenesis of the Pancreas: The Role of Stellate Cells, in The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery, Second Edition (eds H. G. Beger, A. L. Warshaw, M. W. Büchler, R. A. Kozarek, M. M. Lerch, J. P. Neoptolemos, K. Shiratori, D. C. Whitcomb and B. M. Rau), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444300123.ch38

Editor Information

  1. 3

    c/o Universitätsklinikum Ulm, University of Ulm, Germany

  2. 4

    Department of Surgery, Massachusetts General Hospital, Boston, MA, USA

  3. 5

    W. Gerald Austen Professor of Surgery, Harvard Medical School, Boston, MA, USA

  4. 6

    Department of General and Visceral Surgery, University of Heidelberg, Germany

  5. 7

    Digestive Disease Institute, Virginia Mason Medical Center, Seattle, WA, USA

  6. 8

    Department of Gastroenterology, Endocrinology and Nutrition, Ernst-Moritz-Arndt University, Greifswald, Germany

  7. 9

    The Owen and Ellen Evans Chair of Cancer Studies, University of Liverpool, UK

  8. 10

    Division of Surgery and Oncology, University of Liverpool, UK

  9. 11

    School of Cancer Studies, University of Liverpool, UK

  10. 12

    Department of Gastroenterology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan

  11. 13

    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, PA, USA

  12. 14

    Department of General, Thoracic, Vascular and Transplantation Surgery, University of Rostock, Germany

Author Information

  1. 1

    Department of Clinical Chemistry, University Hospital Ulm, Germany

  2. 2

    Department of Surgery, Community Hospital Aelen, Ulm, Germany

Publication History

  1. Published Online: 4 FEB 2009
  2. Published Print: 11 APR 2008

ISBN Information

Print ISBN: 9781405146647

Online ISBN: 9781444300123



  • extensive fibrosis - chronic pancreatitis and pancreatic cancer hallmarks;
  • fibrogenesis in pancreatitis - stellate cell role;
  • fibrogenic mediator identification;
  • mitogen-activated protein kinases (MAPK);
  • ethanol, acetaldehyde, and oxidative stress;
  • PSC autocrine stimulation;
  • stellate cell therapeutic targeting;
  • fibrogenesis in pancreatitis - acinar cell injury and necrosis


This chapter contains sections titled:

  • Introduction

  • Characterization of PSCs: differences from pancreatic fibroblasts

  • Cell biology of PSCs

  • Identification of fibrogenic mediators

  • Paracrine stimulation of PSCs by injured acinar cells, macrophages, lymphocytes, and platelets

  • Interaction of stellate cells with tumor cells

  • Autocrine stimulation of PSCs

  • PSC migration: an additional aspect of pancreatic fibrogenesis (Fig. 38.4)

  • Signaling pathways for activation, proliferation, matrix synthesis, and migration of PSCs

  • Therapeutic targeting of stellate cells

  • Conclusions

  • References