Chapter 45. Molecular understanding of Chronic Pancreatitis

  1. Hans G. Beger MD, FACS(Hon) Founding Editor Emeritus Professor of Surgery1,
  2. Andrew L. Warshaw MD Surgeon-in-Chief Chairman2,3,
  3. Markus W. Büchler MD Chairman Head Professor of Surgery4,
  4. Richard A. Kozarek MD Director5,
  5. Markus M. Lerch MD, FRCP Professor Chair6,
  6. John P. Neoptolemos MA, MB, BChir, MD, FRCS, FMedSci Head Professor of Surgery7,8,9,
  7. Keiko Shiratori MD Chair Professor10,
  8. David C. Whitcomb MD, PhD Professor of Medicine Chief11 and
  9. Bettina M. Rau MD Coordinating Editor Associate Professor of Surgery12
  1. David C. Whitcomb MD, PhD Professor of Medicine Chief

Published Online: 4 FEB 2009

DOI: 10.1002/9781444300123.ch45

The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery, Second Edition

The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery, Second Edition

How to Cite

Whitcomb, D. C. (2008) Molecular understanding of Chronic Pancreatitis, in The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery, Second Edition (eds H. G. Beger, A. L. Warshaw, M. W. Büchler, R. A. Kozarek, M. M. Lerch, J. P. Neoptolemos, K. Shiratori, D. C. Whitcomb and B. M. Rau), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444300123.ch45

Editor Information

  1. 1

    c/o Universitätsklinikum Ulm, University of Ulm, Germany

  2. 2

    Department of Surgery, Massachusetts General Hospital, Boston, MA, USA

  3. 3

    W. Gerald Austen Professor of Surgery, Harvard Medical School, Boston, MA, USA

  4. 4

    Department of General and Visceral Surgery, University of Heidelberg, Germany

  5. 5

    Digestive Disease Institute, Virginia Mason Medical Center, Seattle, WA, USA

  6. 6

    Department of Gastroenterology, Endocrinology and Nutrition, Ernst-Moritz-Arndt University, Greifswald, Germany

  7. 7

    The Owen and Ellen Evans Chair of Cancer Studies, University of Liverpool, UK

  8. 8

    Division of Surgery and Oncology, University of Liverpool, UK

  9. 9

    School of Cancer Studies, University of Liverpool, UK

  10. 10

    Department of Gastroenterology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan

  11. 11

    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, PA, USA

  12. 12

    Department of General, Thoracic, Vascular and Transplantation Surgery, University of Rostock, Germany

Author Information

  1. Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, PA, USA

Publication History

  1. Published Online: 4 FEB 2009
  2. Published Print: 11 APR 2008

ISBN Information

Print ISBN: 9781405146647

Online ISBN: 9781444300123

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Keywords:

  • molecular understanding of chronic pancreatitis;
  • chronic pancreatitis models;
  • sentinel acute pancreatitis event (SAPE) hypothesis model;
  • high-risk PRSS1 mutations;
  • pathologic pathway model;
  • chronic pancreatitis duct obstruction model;
  • chronic pancreatitis susceptibility genes - CFTR, SPINK1, and PRSS1;
  • pancreatic secretory trypsin inhibitor (PSTI) in pancreatic acinar cells

Summary

This chapter contains sections titled:

  • Introduction

  • Models of chronic pancreatitis

  • Human models of chronic pancreatitis

  • Stellate cells: final common pathway of the fibrosis process

  • SAPE hypothesis model

  • Evidence that chronic pancreatitis is the end stage of multiple processes

  • Animal models of human disease

  • References