Chapter 12. The Molecular Pathology of Sporadic and Hereditary Colorectal Cancer

  1. Janusz Jankowski MD, PhD, FRCP, FACG Consultant Gastroenterologist Fellow Professor3,4,5,6,7,
  2. Richard Sampliner MD Professor of Medicine Chief of Gastroenterology8,9,
  3. David Kerr CBE, MA, MD, DSc, FRCP, FMedSci Head of Department of Clinical Pharmacology7,10,11 and
  4. Yuman Fong MD Professor of Surgery12,13
  1. Massimo Pignatelli MD, PhD, FRCPath1,
  2. Nahida Banu MBBS, PhD2 and
  3. Zsombor Melegh MD, MSc1

Published Online: 14 JAN 2009

DOI: 10.1002/9781444300147.ch12

Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach

Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach

How to Cite

Pignatelli, M., Banu, N. and Melegh, Z. (2008) The Molecular Pathology of Sporadic and Hereditary Colorectal Cancer, in Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach (eds J. Jankowski, R. Sampliner, D. Kerr and Y. Fong), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444300147.ch12

Editor Information

  1. 3

    Digestive Diseases Centre UHL Trust, Leicester, UK

  2. 4

    James Black Senior Fellow and Professor, University of Oxford, UK

  3. 5

    Cancer Research, UK

  4. 6

    Queen Mary University of London, UK

  5. 7

    Department of Clinical Pharmacology, University of Oxford, Oxford, UK

  6. 8

    University of Arizona College of Medicine, Tuscon, AZ, USA

  7. 9

    Southern Arizona VA Health Care System, USA

  8. 10

    Rhodes Professor of Cancer Therapeutics and Clinical Pharmacology, University of Oxford, UK

  9. 11

    University of Oxford, UK

  10. 12

    Murray F. Brennan Chair in Surgery, Memorial Sloan-Kettering Cancer Center, New York, USA

  11. 13

    Weill Cornell Medical Center, New York, USA

Author Information

  1. 1

    Department of Cellular and Molecular Medicine, Histopathology Division, Bristol Royal Infirmary, Bristol, UK

  2. 2

    Department of Pathology, Bristol Royal Infirmary, Bristol, UK

Publication History

  1. Published Online: 14 JAN 2009
  2. Published Print: 11 APR 2008

ISBN Information

Print ISBN: 9781405127837

Online ISBN: 9781444300147

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Keywords:

  • molecular pathology of sporadic and hereditary colorectal cancer;
  • familial adenomatous polyposis (AAPC);
  • microsatellite instability in colorectal cancer;
  • human non polyposis colorectal cancer (HNPCC) or Lynch syndrome;
  • sporadic MSI-associated colorectal cancer;
  • CpG island methylation phenotype (CIMP);
  • women and sporadic MSI-H-associated colorectal cancers

Summary

This chapter contains sections titled:

  • References