Chapter 5. Formulating Well-Built Clinical Questions

  1. Hywel Williams MSC, PhD, FRCP Professor Dermato-Epidemiology Co-ordinating Editor
  1. Berthold Rzany MD, ScM1 and
  2. Michael Bigby MD Associate Professor of Dermatology2,3

Published Online: 14 JAN 2009

DOI: 10.1002/9781444300161.ch5

Evidence-Based Dermatology, Second Edition

Evidence-Based Dermatology, Second Edition

How to Cite

Rzany, B. and Bigby, M. (2008) Formulating Well-Built Clinical Questions, in Evidence-Based Dermatology, Second Edition (ed H. Williams), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444300161.ch5

Editor Information

  1. Centre of Evidence-Based Dermatology, Nottingham University Hospital NHS Trust, Queen's Medical Centre, Nottingham, UK

Author Information

  1. 1

    Division of Evidence Based Medicine (dEBM), Klinik für Dermatologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

  2. 2

    Department of Dermatology, Harvard Medical School, Boston, MA, USA

  3. 3

    Beth Israel, Deaconess Medical Center, Boston, MA, USA

Publication History

  1. Published Online: 14 JAN 2009
  2. Published Print: 11 APR 2008

ISBN Information

Print ISBN: 9781405145183

Online ISBN: 9781444300161



  • evidence-based medicine (EBM) centers;
  • well-formed clinical question;
  • PICO (patient, intervention, comparator, and outcome) structure;
  • structuring well-built clinical questions;
  • direct fluorescence antibody (DFA) slide;
  • randomized controlled clinical trials


This chapter contains sections titled:

  • Structuring well-built clinical questions

  • The advantages of well-built clinical questions

  • References