Chapter 61. Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis

  1. Hywel Williams MSC, PhD, FRCP Professor Dermato-Epidemiology Co-ordinating Editor
  1. Pierre-Dominique Ghislain MD1 and
  2. Jean-Claude Roujeau MD, PhD2

Published Online: 14 JAN 2009

DOI: 10.1002/9781444300161.ch61

Evidence-Based Dermatology, Second Edition

Evidence-Based Dermatology, Second Edition

How to Cite

Ghislain, P.-D. and Roujeau, J.-C. (2008) Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis, in Evidence-Based Dermatology, Second Edition (ed H. Williams), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444300161.ch61

Editor Information

  1. Centre of Evidence-Based Dermatology, Nottingham University Hospital NHS Trust, Queen's Medical Centre, Nottingham, UK

Author Information

  1. 1

    Cliniques Universitaires St-Luc, Service de Dermatologie, Brussels, Belgium

  2. 2

    Henri Mondor Hospital, University Paris XII, Créteil, France

Publication History

  1. Published Online: 14 JAN 2009
  2. Published Print: 11 APR 2008

ISBN Information

Print ISBN: 9781405145183

Online ISBN: 9781444300161



  • Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN);
  • Simplified Acute Physiology Score (SAPS and SAPS II);
  • SJS and positive Nikolsky sign with epidermal detachment;
  • intravenous immunoglobulin (IVIG) in patients with TEN;
  • cyclophosphamide - therapeutic effectiveness;
  • early referral to specialized medical units;
  • drug culpability tests;
  • erythema multiforme (EM)


This chapter contains sections titled:

  • Background

  • Questions

  • References