Chapter 1. Protocols for Diagnosing Myocardial Infarction

  1. James A. de Lemos MD Associate Professor of Medicine Coronary Care Unit Director
  1. James McCord MD

Published Online: 13 JAN 2009

DOI: 10.1002/9781444300208.ch1

Biomarkers in Heart Disease

Biomarkers in Heart Disease

How to Cite

McCord, J. (2008) Protocols for Diagnosing Myocardial Infarction, in Biomarkers in Heart Disease (ed J. A. de Lemos), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444300208.ch1

Editor Information

  1. University of Texas Southwestern Medical Center Dallas, TX, USA

Author Information

  1. Henry Ford Heart and Vascular Institute, Henry Ford Health System, Detroit, MI, USA

Publication History

  1. Published Online: 13 JAN 2009
  2. Published Print: 18 APR 2008

Book Series:

  1. The AHA Clinical Series

Book Series Editors:

  1. Elliott Antman

ISBN Information

Print ISBN: 9781405175715

Online ISBN: 9781444300208



  • cardiac marker protocols in myocardial infarction (MI) diagnosis;
  • point-of-care (POC);
  • necrosis cardiac markers and Emergency Departments (EDs);
  • candidate markers and kinetics;
  • creatine kinase (CK)-MB - myocardial necrosis common marker;
  • cardiac troponin I and T;
  • myoglobin in MI diagnosis;
  • ST-segment elevation myocardial infarction (STEMI)


This chapter contains sections titled:

  • Introduction

  • Candidate markers and kinetics

  • Point-of-care testing

  • Serial sampling of cardiac markers

  • Multimarker strategies and analysis of dynamic change in markers over time

  • Improved troponin assays: cut-points, precision, and implications for the role of myoglobin and CK-MB

  • References