Chapter 6. Use of Natriuretic Peptides in the Diagnosis of Heart Failure

  1. James A. de Lemos MD Associate Professor of Medicine Coronary Care Unit Director
  1. Abelardo Martinez-Rumayor MD and
  2. James L. Januzzi MD, FACC

Published Online: 13 JAN 2009

DOI: 10.1002/9781444300208.ch6

Biomarkers in Heart Disease

Biomarkers in Heart Disease

How to Cite

Martinez-Rumayor, A. and Januzzi, J. L. (2008) Use of Natriuretic Peptides in the Diagnosis of Heart Failure, in Biomarkers in Heart Disease (ed J. A. de Lemos), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444300208.ch6

Editor Information

  1. University of Texas Southwestern Medical Center Dallas, TX, USA

Author Information

  1. Department of Medicine and Division of Cardiology, Massachusetts General Hospital, Boston, MA, USA

Publication History

  1. Published Online: 13 JAN 2009
  2. Published Print: 18 APR 2008

Book Series:

  1. The AHA Clinical Series

Book Series Editors:

  1. Elliott Antman

ISBN Information

Print ISBN: 9781405175715

Online ISBN: 9781444300208



  • natriuretic peptide system biology;
  • natriuretic peptides in heart failure (HF) diagnosis;
  • pro-BNP, BNP and NT-proBNP biochemical structure;
  • HF and natriuretic peptide (NP) testing;
  • Rapid Emergency Department Heart Failure Trial (REDHOT) study;
  • natriuretic peptide testing in primary care outpatient evaluation;
  • gray zone values;
  • natriuretic peptide concentrations and important modifiers


This chapter contains sections titled:

  • Biology of the natriuretic peptide system

  • Major studies and operating characteristics

  • Gray zone values

  • Pitfalls

  • References