Chapter 1. General Introduction: Evaluation of Diagnostic Procedures

  1. J. André Knottnerus MD, PhD Professor of General Practice President2,3 and
  2. Frank Buntinx MD, PhD Professor4,5,6
  1. J. André Knottnerus MD, PhD Professor of General Practice President2,3,
  2. Frank Buntinx MD, PhD Professor4,5,6 and
  3. Chris van Weel MD, FRCGP, FRACGP Professor of General Practice1

Published Online: 2 FEB 2009

DOI: 10.1002/9781444300574.ch1

The Evidence Base of Clinical Diagnosis: Theory and methods of diagnostic research, Second Edition

The Evidence Base of Clinical Diagnosis: Theory and methods of diagnostic research, Second Edition

How to Cite

Knottnerus, J. A., Buntinx, F. and van Weel, C. (2008) General Introduction: Evaluation of Diagnostic Procedures, in The Evidence Base of Clinical Diagnosis: Theory and methods of diagnostic research, Second Edition (eds J. A. Knottnerus and F. Buntinx), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300574.ch1

Editor Information

  1. 2

    Netherlands School of Primary Care Research, Maastricht University, The Hague, The Netherlands

  2. 3

    The Health Council of The Netherlands, The Hague, The Netherlands

  3. 4

    Department of General Practice, Catholic University Leuven, Belgium

  4. 5

    Netherlands School of Primary Care Research, Maastricht University, Maastricht, The Netherlands

  5. 6

    Department of General Practice, Maastricht University, Maastricht, The Netherlands

Author Information

  1. 1

    Hon. Fellow of the Royal College of General Practitioners and of the Royal Australian College of General Practitioners, Radboud University Medical Centre, Department of General Practice, Nijmegen, The Netherlands

  2. 2

    Netherlands School of Primary Care Research, Maastricht University, The Hague, The Netherlands

  3. 3

    The Health Council of The Netherlands, The Hague, The Netherlands

  4. 4

    Department of General Practice, Catholic University Leuven, Belgium

  5. 5

    Netherlands School of Primary Care Research, Maastricht University, Maastricht, The Netherlands

  6. 6

    Department of General Practice, Maastricht University, Maastricht, The Netherlands

Publication History

  1. Published Online: 2 FEB 2009
  2. Published Print: 10 OCT 2008

ISBN Information

Print ISBN: 9781405157872

Online ISBN: 9781444300574

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Keywords:

  • evidence base of clinical diagnosis;
  • development of diagnostic technologies and funding;
  • performance of tests evaluated with their intended objectives;
  • diagnostic procedures and methodological challenges;
  • discriminatory power of test and “gold” standard problem;
  • dominance of prevailing reference standards;
  • spectrum and selection bias;
  • observer variability and observer bias;
  • synthesizing research findings and clinical expertise;
  • diagnostic technology assessment

Summary

This chapter contains sections titled:

  • Introduction

  • Objectives

  • Methodological challenges

  • Research designs

  • Concluding remarks

  • References