Chapter 10. Guidelines for Conducting Systematic Reviews of Studies Evaluating the Accuracy of Diagnostic Tests

  1. J. André Knottnerus MD, PhD Professor of General Practice President3,4 and
  2. Frank Buntinx MD, PhD Professor5,6,7
  1. Frank Buntinx MD, PhD Professor5,6,7,
  2. Bert Aertgeerts MD, PhD Professor of General Practice Director1 and
  3. Petra Macaskill BA, MAppStat, PhD2

Published Online: 2 FEB 2009

DOI: 10.1002/9781444300574.ch10

The Evidence Base of Clinical Diagnosis: Theory and methods of diagnostic research, Second Edition

The Evidence Base of Clinical Diagnosis: Theory and methods of diagnostic research, Second Edition

How to Cite

Buntinx, F., Aertgeerts, B. and Macaskill, P. (2008) Guidelines for Conducting Systematic Reviews of Studies Evaluating the Accuracy of Diagnostic Tests, in The Evidence Base of Clinical Diagnosis: Theory and methods of diagnostic research, Second Edition (eds J. A. Knottnerus and F. Buntinx), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300574.ch10

Editor Information

  1. 3

    Netherlands School of Primary Care Research, Maastricht University, The Hague, The Netherlands

  2. 4

    The Health Council of The Netherlands, The Hague, The Netherlands

  3. 5

    Department of General Practice, Catholic University Leuven, Belgium

  4. 6

    Netherlands School of Primary Care Research, Maastricht University, Maastricht, The Netherlands

  5. 7

    Department of General Practice, Maastricht University, Maastricht, The Netherlands

Author Information

  1. 1

    The Belgian Centre of Evidence-Based Medicine, Kapucijnenvoer, Leuven, Belgium

  2. 2

    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, Australia

  3. 5

    Department of General Practice, Catholic University Leuven, Belgium

  4. 6

    Netherlands School of Primary Care Research, Maastricht University, Maastricht, The Netherlands

  5. 7

    Department of General Practice, Maastricht University, Maastricht, The Netherlands

Publication History

  1. Published Online: 2 FEB 2009
  2. Published Print: 10 OCT 2008

ISBN Information

Print ISBN: 9781405157872

Online ISBN: 9781444300574

SEARCH

Keywords:

  • studies evaluating diagnostic accuracy;
  • diagnostic and screening tests - accuracy evaluation;
  • MeSH term use - MEDLINE;
  • EMBASE and CENTRAL;
  • Search strategies and PubMed for MEDLINE;
  • Latin American Caribbean Health Sciences Literature (LILACS);
  • Cumulative Index of Nursing and Allied Health (CINAHL);
  • chance-adjusted agreement reporting and disagreements by consensus or arbitration;
  • modified QUADAS tool and generalizability or applicability of results (spectrum bias);
  • data extraction;
  • degree of heterogeneity between studies - measure of differences

Summary

This chapter contains sections titled:

  • Introduction

  • How to search the literature for studies evaluating the accuracy of diagnostic tests

  • Methodological quality

  • Data extraction

  • Data analysis

  • Describing the results of individual studies

  • Searching for heterogeneity

  • Dealing with heterogeneity

  • Deciding on the statistical model to be used

  • Statistical pooling

  • Hierarchical models

  • Data presentation

  • Appendix 1: A flowchart of the searching and selection process.

  • Appendix 2: Other databases of significance to reviewers

  • Appendix 3

  • References