Chapter 4. Diagnostic Testing and Prognosis: The Randomized Controlled Trial in Test Evaluation Research

  1. J. André Knottnerus MD, PhD Professor of General Practice President3,4 and
  2. Frank Buntinx MD, PhD Professor5,6,7
  1. Jeroen G. Lijmer MD, PhD1 and
  2. Patrick M. M. Bossuyt Professor of Clinical Epidemiology2

Published Online: 2 FEB 2009

DOI: 10.1002/9781444300574.ch4

The Evidence Base of Clinical Diagnosis: Theory and methods of diagnostic research, Second Edition

The Evidence Base of Clinical Diagnosis: Theory and methods of diagnostic research, Second Edition

How to Cite

Lijmer, J. G. and Bossuyt, P. M. M. (2008) Diagnostic Testing and Prognosis: The Randomized Controlled Trial in Test Evaluation Research, in The Evidence Base of Clinical Diagnosis: Theory and methods of diagnostic research, Second Edition (eds J. A. Knottnerus and F. Buntinx), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300574.ch4

Editor Information

  1. 3

    Netherlands School of Primary Care Research, Maastricht University, The Hague, The Netherlands

  2. 4

    The Health Council of The Netherlands, The Hague, The Netherlands

  3. 5

    Department of General Practice, Catholic University Leuven, Belgium

  4. 6

    Netherlands School of Primary Care Research, Maastricht University, Maastricht, The Netherlands

  5. 7

    Department of General Practice, Maastricht University, Maastricht, The Netherlands

Author Information

  1. 1

    Department of Psychiatry, Waterland Hospital, Purmerend, The Netherlands

  2. 2

    Department Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Publication History

  1. Published Online: 2 FEB 2009
  2. Published Print: 10 OCT 2008

ISBN Information

Print ISBN: 9781405157872

Online ISBN: 9781444300574

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Keywords:

  • diagnostic testing and prognosis;
  • basic RCT of single diagnostic test;
  • randomizing abnormal test results;
  • treatment effect in test normals and treatment effect in test abnormals;
  • intrauterine growth retardation (IUGR);
  • alternative randomized designs;
  • comparing test strategies;
  • RCT of two tests randomizing only discordant results;
  • flexible endoscopic valuation of swallowing with sensory testing (FEESST);
  • prognostic impact of tests evaluation

Summary

This chapter contains sections titled:

  • Why bother about the prognostic impact of a diagnostic test?

  • How to measure prognostic impact of a test

  • Alternative randomized designs

  • How to compare test strategies

  • Choice of design

  • Practical issues

  • Conclusions

  • References