Chapter 6. Designing Studies to Ensure that Estimates of Test Accuracy Will Travel

  1. J. André Knottnerus MD, PhD Professor of General Practice President6,7 and
  2. Frank Buntinx MD, PhD Professor8,9,10
  1. Les M. Irwig MBBCh, PhD Professor of Epidemiology1,
  2. Patrick M. M. Bossuyt Professor of Clinical Epidemiology2,
  3. Paul P. Glasziou FRACGP, PhD Director3,
  4. Constantine Gatsonis PhD Professor of Medical Science (Biostatistics) Director4 and
  5. Jeroen G. Lijmer MD, PhD5

Published Online: 2 FEB 2009

DOI: 10.1002/9781444300574.ch6

The Evidence Base of Clinical Diagnosis: Theory and methods of diagnostic research, Second Edition

The Evidence Base of Clinical Diagnosis: Theory and methods of diagnostic research, Second Edition

How to Cite

Irwig, L. M., Bossuyt, P. M. M., Glasziou, P. P., Gatsonis, C. and Lijmer, J. G. (2008) Designing Studies to Ensure that Estimates of Test Accuracy Will Travel, in The Evidence Base of Clinical Diagnosis: Theory and methods of diagnostic research, Second Edition (eds J. A. Knottnerus and F. Buntinx), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300574.ch6

Editor Information

  1. 6

    Netherlands School of Primary Care Research, Maastricht University, The Hague, The Netherlands

  2. 7

    The Health Council of The Netherlands, The Hague, The Netherlands

  3. 8

    Department of General Practice, Catholic University Leuven, Belgium

  4. 9

    Netherlands School of Primary Care Research, Maastricht University, Maastricht, The Netherlands

  5. 10

    Department of General Practice, Maastricht University, Maastricht, The Netherlands

Author Information

  1. 1

    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, Australia

  2. 2

    Department Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

  3. 3

    Centre for Evidence-Based Medicine, Department of Primary Health Care, University of Oxford, Oxford, UK

  4. 4

    Center for Statistical Sciences, Brown University, Providence, Rhode Island, USA

  5. 5

    Department of Psychiatry, Waterland Hospital, Purmerend, The Netherlands

Publication History

  1. Published Online: 2 FEB 2009
  2. Published Print: 10 OCT 2008

ISBN Information

Print ISBN: 9781405157872

Online ISBN: 9781444300574

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Keywords:

  • ensuring estimates of test accuracy;
  • measures of test accuracy as fixed characteristics;
  • diagnostic test performance - discrimination and calibration;
  • transferability of test results;
  • test performance measures and first two assumptions;
  • choosing relevant reference standard;
  • population/clinical question - symptoms, signs;
  • accuracy of test in primary care;
  • replacement or incremental test;
  • value of designing studies

Summary

This chapter contains sections titled:

  • Introduction

  • Reasons for true variability in test accuracy: conceptual underpinnings

  • Implications of variation in discriminative power and calibration of tests: questions to ask yourself before you start designing the study

  • Concluding remarks

  • Acknowledgments

  • References