Chapter 1. Basic Design Considerations

  1. David Machin1,2,3,
  2. Michael J. Campbell3,
  3. Say Beng Tan4,5 and
  4. Sze Huey Tan2

Published Online: 30 JAN 2009

DOI: 10.1002/9781444300710.ch1

Sample Size Tables for Clinical Studies, Third Edition

Sample Size Tables for Clinical Studies, Third Edition

How to Cite

Machin, D., Campbell, M. J., Tan, S. B. and Tan, S. H. (2008) Basic Design Considerations, in Sample Size Tables for Clinical Studies, Third Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300710.ch1

Author Information

  1. 1

    Children's Cancer and Leukaemia Group, University of Leicester, UK

  2. 2

    Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore

  3. 3

    Medical Statistics Unit, School of Health and Related Sciences, University of Sheffield, UK

  4. 4

    Singapore Clinical Research Institute, Singapore

  5. 5

    Duke–NUS Graduate Medical School, Singapore

Publication History

  1. Published Online: 30 JAN 2009
  2. Published Print: 21 NOV 2008

ISBN Information

Print ISBN: 9781405146500

Online ISBN: 9781444300710



  • sample size calculations;
  • statistical issues relevant to sample-size calculations;
  • sample-size determination in different situations;
  • design and analysis;
  • basic design considerations;
  • sample-size calculation software;
  • tables and associated software;
  • internal pilot studies and sample size estimations


This chapter contains sections titled:

  • Why sample size calculations?

  • Design and analysis

  • Practicalities

  • Use of tables and software

  • The protocol

  • Books on sample-size calculations

  • Software for sample-size calculations

  • References