Chapter 15. Dose Finding Studies

  1. David Machin1,2,3,
  2. Michael J. Campbell3,
  3. Say Beng Tan4,5 and
  4. Sze Huey Tan2

Published Online: 30 JAN 2009

DOI: 10.1002/9781444300710.ch15

Sample Size Tables for Clinical Studies, Third Edition

Sample Size Tables for Clinical Studies, Third Edition

How to Cite

Machin, D., Campbell, M. J., Tan, S. B. and Tan, S. H. (2008) Dose Finding Studies, in Sample Size Tables for Clinical Studies, Third Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300710.ch15

Author Information

  1. 1

    Children's Cancer and Leukaemia Group, University of Leicester, UK

  2. 2

    Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore

  3. 3

    Medical Statistics Unit, School of Health and Related Sciences, University of Sheffield, UK

  4. 4

    Singapore Clinical Research Institute, Singapore

  5. 5

    Duke–NUS Graduate Medical School, Singapore

Publication History

  1. Published Online: 30 JAN 2009
  2. Published Print: 21 NOV 2008

ISBN Information

Print ISBN: 9781405146500

Online ISBN: 9781444300710



  • dose finding studies;
  • clinical trial designs;
  • concept of dose limiting toxicity (DLT);
  • choosing which doses to test;
  • step-by-step designs;
  • maximum tolerated dose (MTD) in C33D for Phase I trial;
  • continual reassessment method;
  • Bayes and Maximum Likelihood;
  • CRM method and C33D and Best-of-5 designs


This chapter contains sections titled:

  • Introduction

  • Choosing which doses to test

  • Step-by-step designs

  • Continual reassessment method

  • Which design?

  • Bibliography

  • Examples

  • References