Chapter 12. Cholecystokinin Antagonists

  1. Gary J. McCleane MD, FFARCSI, DA, DipIMC, Dip Pain Mang Consultant in Pain Management

Published Online: 30 JAN 2009

DOI: 10.1002/9781444300796.ch12

Pain Management: Expanding the Pharmacological Options

Pain Management: Expanding the Pharmacological Options

How to Cite

McCleane, G. J. (2008) Cholecystokinin Antagonists, in Pain Management: Expanding the Pharmacological Options, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300796.ch12

Author Information

  1. Rampark Pain Centre, Lurgan, Northern Ireland, Ireland

Publication History

  1. Published Online: 30 JAN 2009
  2. Published Print: 6 JUN 2008

ISBN Information

Print ISBN: 9781405178235

Online ISBN: 9781444300796

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Keywords:

  • cholecystokinin in nervous system;
  • cholecystokinin as anti-opioid peptide;
  • cholecystokinin antagonists;
  • CCK antagonist enhancing antinociceptive effect of opioid;
  • CCK antagonists on antinociceptive tolerance to opioids;
  • reversal of established tolerance;
  • safety of CCK antagonists

Summary

This chapter contains sections titled:

  • Cholecystokinin

  • Role of cholecystokinin in the nervous system

  • Cholecystokinin as an anti-opioid peptide

  • Cholecystokinin antagonists

  • Effect of CCK antagonists on opioid-derived antinociception

  • Effect of CCK antagonists on antinociceptive tolerance to opioids

  • Reversal of established tolerance

  • Safety of CCK antagonists

  • Human studies

  • Other potential effects of CCK antagonists

  • Human use

  • Conclusions

  • Bibliography