Chapter 4. Topical Nitrates

  1. Gary J. McCleane MD, FFARCSI, DA, DipIMC, Dip Pain Mang Consultant in Pain Management

Published Online: 30 JAN 2009

DOI: 10.1002/9781444300796.ch4

Pain Management: Expanding the Pharmacological Options

Pain Management: Expanding the Pharmacological Options

How to Cite

McCleane, G. J. (2009) Topical Nitrates, in Pain Management: Expanding the Pharmacological Options, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300796.ch4

Author Information

  1. Rampark Pain Centre, Lurgan, Northern Ireland, Ireland

Publication History

  1. Published Online: 30 JAN 2009
  2. Published Print: 6 JUN 2008

ISBN Information

Print ISBN: 9781405178235

Online ISBN: 9781444300796

SEARCH

Keywords:

  • topical nitrates;
  • human experimental pain;
  • endogenous NO in analgesic tolerance;
  • nitrates significant effect on smooth muscle;
  • glyceryl trinitrate as co-analgesic;
  • glyceryl trinitrate formulations;
  • topical application of GTN for simple, low-risk option in localized pain

Summary

This chapter contains sections titled:

  • Mode of action of topical nitrates when used as analgesics

  • Human experimental pain

  • Human clinical pain

  • Effect of topical nitrates on analgesic effect of opioids

  • Glyceryl trinitrate as a co-analgesic

  • Unresolved issues with the use of topical glyceryl trinitrate

  • Glyceryl trinitrate formulations

  • Side effects of topical application of glyceryl trinitrate

  • Suggested clinical use

  • Conclusions

  • Bibliography