Chapter 4. Topical Nitrates
Published Online: 30 JAN 2009
DOI: 10.1002/9781444300796.ch4
Copyright © 2008 Gary J. McCleane
Book Title
Pain Management: Expanding the Pharmacological Options
Additional Information
How to Cite
McCleane, G. J. (2009) Topical Nitrates, in Pain Management: Expanding the Pharmacological Options, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300796.ch4
Publication History
- Published Online: 30 JAN 2009
- Published Print: 6 JUN 2008
ISBN Information
Print ISBN: 9781405178235
Online ISBN: 9781444300796
- Summary
- Chapter
Keywords:
- topical nitrates;
- human experimental pain;
- endogenous NO in analgesic tolerance;
- nitrates significant effect on smooth muscle;
- glyceryl trinitrate as co-analgesic;
- glyceryl trinitrate formulations;
- topical application of GTN for simple, low-risk option in localized pain
Summary
This chapter contains sections titled:
Mode of action of topical nitrates when used as analgesics
Human experimental pain
Human clinical pain
Effect of topical nitrates on analgesic effect of opioids
Glyceryl trinitrate as a co-analgesic
Unresolved issues with the use of topical glyceryl trinitrate
Glyceryl trinitrate formulations
Side effects of topical application of glyceryl trinitrate
Suggested clinical use
Conclusions
Bibliography