Chapter 5. Topical Tricyclic Antidepressants

  1. Gary J. McCleane MD, FFARCSI, DA, DipIMC, Dip Pain Mang Consultant in Pain Management

Published Online: 30 JAN 2009

DOI: 10.1002/9781444300796.ch5

Pain Management: Expanding the Pharmacological Options

Pain Management: Expanding the Pharmacological Options

How to Cite

McCleane, G. J. (2008) Topical Tricyclic Antidepressants, in Pain Management: Expanding the Pharmacological Options, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300796.ch5

Author Information

  1. Rampark Pain Centre, Lurgan, Northern Ireland, Ireland

Publication History

  1. Published Online: 30 JAN 2009
  2. Published Print: 6 JUN 2008

ISBN Information

Print ISBN: 9781405178235

Online ISBN: 9781444300796

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Keywords:

  • tricyclic antidepressants (TCAs);
  • mode of action of tricyclic antidepressants;
  • adenosine A3 receptor activation and pain behaviors;
  • experimentally induced neuropathic pain models;
  • formalin test - chronic inflammatory pain model;
  • topical TCA and small area of pain;
  • TCA containing preparation for topical application in pain

Summary

This chapter contains sections titled:

  • Mode of action of tricyclic antidepressants

  • Experimental evidence

  • Animal evidence of an antinociceptive effect of peripherally applied TCAs

  • Human pain

  • Conditions which may benefit from topical TCA

  • Suggested clinical use

  • Bibliography