Chapter 1. Rating the Quality of Evidence and Making Recommendations: A Guide to the Spectrum of Clinical Research

  1. Mark A. Crowther MD, MSc, FRCPC Professor Division Director5,6,
  2. Jeff Ginsberg MD, FRCPC Professor7,
  3. Holger J. Schünemann MD, PhD, MSc, FACP, FCCP Professor8,9,
  4. Ralph M. Meyer MD, FRCPC Director Professor10,11 and
  5. Richard Lottenberg MD, FACP Professor12
  1. Holger J. Schünemann MD, PhD, MSc, FACP, FCCP Professor8,9,
  2. Martin Stanulla MD, MSc1,
  3. Jan L. Brozek MD, PhD2,3 and
  4. Gordon G. Guyatt MD, MSc4

Published Online: 4 FEB 2009

DOI: 10.1002/9781444300857.ch1

Evidence-Based Hematology

Evidence-Based Hematology

How to Cite

Schünemann, H. J., Stanulla, M., Brozek, J. L. and Guyatt, G. G. (2009) Rating the Quality of Evidence and Making Recommendations: A Guide to the Spectrum of Clinical Research, in Evidence-Based Hematology (eds M. A. Crowther, J. Ginsberg, H. J. Schünemann, R. M. Meyer and R. Lottenberg), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300857.ch1

Editor Information

  1. 5

    Division of Hematology, McMaster University, Hamilton, Ontario, Canada

  2. 6

    St. Joseph's Hospital, Hamilton, Ontario, Canada

  3. 7

    Department of Medicine, McMaster University, Hamilton, Canada

  4. 8

    CLARITY Research Group, Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy

  5. 9

    McMaster University, Hamilton, Canada

  6. 10

    National Cancer Institute of Canada, Clinical Trials Group, Edith Eisenhauer Chair in Clinical Cancer Research, Queen's University, Kingston, Ontario, Canada

  7. 11

    Departments of Oncology and Medicine, Queen's University, Kingston, Ontario, Canada

  8. 12

    Division of Hematology/Oncology, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA

Author Information

  1. 1

    Department of Pediatric Hematology and Oncology, Children's Hospital, Hannover Medical School, Hannover, Germany

  2. 2

    Italian National Cancer Institute “Regina Elena”, Rome, Italy

  3. 3

    Polish Institute for EBM, Krakow, Poland

  4. 4

    CLARITY Research Group, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada

  5. 8

    CLARITY Research Group, Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy

  6. 9

    McMaster University, Hamilton, Canada

Publication History

  1. Published Online: 4 FEB 2009
  2. Published Print: 27 JUN 2008

ISBN Information

Print ISBN: 9781405157476

Online ISBN: 9781444300857

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Keywords:

  • clinicians requiring clinical expertise to integrate patient's circumstances and values;
  • evidence-based hematology;
  • systematic approach to grading quality of evidence;
  • clinical questions relevant to hematology practice;
  • grading recommendations;
  • evaluating quality of evidence and making recommendations;
  • implications of strong and weak recommendations;
  • methodologic quality of evidence contributing to strength of recommendation;
  • factors increasing quality of evidence

Summary

This chapter contains sections titled:

  • Introduction

  • Question formulation and recommendations in this book

  • Evaluating the quality of evidence and making recommendations

  • Strength of the recommendation

  • Interpreting strong and weak recommendations

  • How methodologic quality of the evidence contributes to strength of recommendation

  • Interpreting the recommendations

  • Summary

  • References