Chapter 16. Evidence-Based Approach to the Diagnosis and Management of Thrombotic Thrombocytopenic Purpura

  1. Mark A. Crowther MD, MSc, FRCPC Professor Division Director3,4,
  2. Jeff Ginsberg MD, FRCPC Professor5,
  3. Holger J. Schünemann MD, PhD, MSc, FACP, FCCP Professor6,7,
  4. Ralph M. Meyer MD, FRCPC Director Professor8,9,
  5. Richard Lottenberg MD, FACP Professor10
  1. Brian Boulmay MD1,
  2. Craig S. Kitchens MD, MACP2

Published Online: 4 FEB 2009

DOI: 10.1002/9781444300857.ch16

Book Title

Evidence-Based Hematology

Evidence-Based Hematology

Additional Information

How to Cite

Boulmay, B. and Kitchens, C. S. (2009) Evidence-Based Approach to the Diagnosis and Management of Thrombotic Thrombocytopenic Purpura, in Evidence-Based Hematology (eds M. A. Crowther, J. Ginsberg, H. J. Schünemann, R. M. Meyer and R. Lottenberg), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300857.ch16

Editor Information

  1. 3

    Division of Hematology, McMaster University, Hamilton, Ontario, Canada

  2. 4

    St. Joseph's Hospital, Hamilton, Ontario, Canada

  3. 5

    Department of Medicine, McMaster University, Hamilton, Canada

  4. 6

    CLARITY Research Group, Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy

  5. 7

    McMaster University, Hamilton, Canada

  6. 8

    National Cancer Institute of Canada, Clinical Trials Group, Edith Eisenhauer Chair in Clinical Cancer Research, Queen's University, Kingston, Ontario, Canada

  7. 9

    Departments of Oncology and Medicine, Queen's University, Kingston, Ontario, Canada

  8. 10

    Division of Hematology/Oncology, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA

Author Information

  1. 1

    Department of Medicine, Health Science Center, University of Florida, Gainesville, Florida, USA

  2. 2

    Veterans Affairs Medical Center, University of Florida, Gainesville, Florida, USA

Publication History

  1. Published Online: 4 FEB 2009
  2. Published Print: 27 JUN 2008

ISBN Information

Print ISBN: 9781405157476

Online ISBN: 9781444300857

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Keywords:

  • thrombotic thrombocytopenic purpura (TTP);
  • diagnostic criteria for TTP;
  • therapeutic plasma exchange and plasma infusion in TTP;
  • cryoprecipitate-poor plasma for TTP treatment;
  • antiplatelet agent role in treatment of TTP;
  • glucocorticosteroid role in TTP treatment;
  • immunosuppressive strategies in TTP;
  • role of rituximab in TTP

Summary

This chapter contains sections titled:

  • What are the Diagnostic Criteria for TTP?

  • Is therapeutic plasma exchange superior to plasma infusion for the treatment of TTP?

  • Is cryoprecipitate-poor plasma preferred over FFP for treatment of TTP?

  • Do antiplatelet agents have a role in the treatment of TTP?

  • Do glucocorticosteroids have a role in the treatment of TTP?

  • In early remission should TPE be tapered or stopped?

  • Are there differing categories of TTP and does the differentiation guide therapy?

  • What is the role of rituximab in the treatment of TTP?

  • References

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