Chapter 18. Diagnosis and Management of Hereditary Bleeding Disorders: Including Congenital/Acquired Platelet Function Disorders

  1. Mark A. Crowther MD, MSc, FRCPC Professor Division Director3,4,
  2. Jeff Ginsberg MD, FRCPC Professor5,
  3. Holger J. Schünemann MD, PhD, MSc, FACP, FCCP Professor6,7,
  4. Ralph M. Meyer MD, FRCPC Director Professor8,9 and
  5. Richard Lottenberg MD, FACP Professor10
  1. Nigel S. Key MB, ChB, FRCP(UK)1 and
  2. Alice D. Ma MD2

Published Online: 4 FEB 2009

DOI: 10.1002/9781444300857.ch18

Evidence-Based Hematology

Evidence-Based Hematology

How to Cite

Key, N. S. and Ma, A. D. (2008) Diagnosis and Management of Hereditary Bleeding Disorders: Including Congenital/Acquired Platelet Function Disorders, in Evidence-Based Hematology (eds M. A. Crowther, J. Ginsberg, H. J. Schünemann, R. M. Meyer and R. Lottenberg), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300857.ch18

Editor Information

  1. 3

    Division of Hematology, McMaster University, Hamilton, Ontario, Canada

  2. 4

    St. Joseph's Hospital, Hamilton, Ontario, Canada

  3. 5

    Department of Medicine, McMaster University, Hamilton, Canada

  4. 6

    CLARITY Research Group, Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy

  5. 7

    McMaster University, Hamilton, Canada

  6. 8

    National Cancer Institute of Canada, Clinical Trials Group, Edith Eisenhauer Chair in Clinical Cancer Research, Queen's University, Kingston, Ontario, Canada

  7. 9

    Departments of Oncology and Medicine, Queen's University, Kingston, Ontario, Canada

  8. 10

    Division of Hematology/Oncology, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA

Author Information

  1. 1

    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

  2. 2

    University of North Carolina School of Medicine, Division of Hematology/Oncology, Harold R. Roberts Comprehensive Hemophilia Center, CB, Chapel Hill, North Carolina, USA

Publication History

  1. Published Online: 4 FEB 2009
  2. Published Print: 27 JUN 2008

ISBN Information

Print ISBN: 9781405157476

Online ISBN: 9781444300857

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Keywords:

  • hereditary bleeding disorders;
  • inherited disorders of hemostasis;
  • von Willebrand disease (vWD) and inherited intrinsic platelet defects;
  • PFA-100R closure times in congenital platelet disorders;
  • PFA-100 in diagnostic evaluation of primary hemostasis disorders;
  • hemarthrosis in hemophilia patients with high titer FVIII inhibitors;
  • Randomized control trials (RCTs) of FVIII/FIX bypassing agents (PCC);
  • acute hemarthrosis requiring bypassing therapy;
  • rFVIIa and FEIBA - equivalent in hemostatic effect

Summary

This chapter contains sections titled:

  • Introduction

  • References