Chapter 20. Diagnosis and Management of Heparin-Induced Thrombocytopenia
- Mark A. Crowther MD, MSc, FRCPC Professor Division Director4,5,
- Jeff Ginsberg MD, FRCPC Professor6,
- Holger J. Schünemann MD, PhD, MSc, FACP, FCCP Professor7,8,
- Ralph M. Meyer MD, FRCPC Director Professor9,10 and
- Richard Lottenberg MD, FACP Professor11
Published Online: 4 FEB 2009
Copyright © 2008 Blackwell Publishing Ltd
How to Cite
Warkentin, T. E. and Greinacher, A. (2008) Diagnosis and Management of Heparin-Induced Thrombocytopenia, in Evidence-Based Hematology (eds M. A. Crowther, J. Ginsberg, H. J. Schünemann, R. M. Meyer and R. Lottenberg), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300857.ch20
Division of Hematology, McMaster University, Hamilton, Ontario, Canada
St. Joseph's Hospital, Hamilton, Ontario, Canada
Department of Medicine, McMaster University, Hamilton, Canada
CLARITY Research Group, Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy
McMaster University, Hamilton, Canada
National Cancer Institute of Canada, Clinical Trials Group, Edith Eisenhauer Chair in Clinical Cancer Research, Queen's University, Kingston, Ontario, Canada
Departments of Oncology and Medicine, Queen's University, Kingston, Ontario, Canada
Division of Hematology/Oncology, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
- Published Online: 4 FEB 2009
- Published Print: 27 JUN 2008
Print ISBN: 9781405157476
Online ISBN: 9781444300857
- Heparin-induced thrombocytopenia (HIT) - acquired, transient, prothrombotic disorder;
- Heparin-Induced Thrombocytopenia;
- alternative anticoagulants for treatment of thrombosis complicating HIT;
- pretest probability of HIT - The “4 T's” scoring system;
- alternative anticoagulants used to treat HIT;
- warfarin (coumarin) anticoagulation - contraindicated during acute HIT;
- natural history of isolated HIT?;
- routine platelet count monitoring for HIT;
- UFH - drug-of-choice for management of cardiac and vascular surgery with previous HIT
This chapter contains sections titled:
What are the clinical features that suggest a diagnosis of HIT?
What laboratory tests are clinically useful for detecting HIT antibodies?
What alternative anticoagulants are efficacious for treatment of thrombosis complicating HIT?
Why is warfarin (coumarin) anticoagulation contraindicated during acute HIT?
What is the natural history of isolated HIT?
Can HIT be prevented?
Should routine platelet count monitoring for HIT be performed in some circumstances?
Is deliberate reexposure to heparin ever warranted in a patient with previous HIT?