Chapter 21. Management of Antiphospholipid Antibody Syndrome

  1. Mark A. Crowther MD, MSc, FRCPC Professor Division Director1,2,
  2. Jeff Ginsberg MD, FRCPC Professor3,
  3. Holger J. Schünemann MD, PhD, MSc, FACP, FCCP Professor4,5,
  4. Ralph M. Meyer MD, FRCPC Director Professor6,7 and
  5. Richard Lottenberg MD, FACP Professor8
  1. Wendy Lim MD, MSc2,3 and
  2. Mark A. Crowther MD, MSc, FRCPC Professor Division Director1,2

Published Online: 4 FEB 2009

DOI: 10.1002/9781444300857.ch21

Evidence-Based Hematology

Evidence-Based Hematology

How to Cite

Lim, W. and Crowther, M. A. (2009) Management of Antiphospholipid Antibody Syndrome, in Evidence-Based Hematology (eds M. A. Crowther, J. Ginsberg, H. J. Schünemann, R. M. Meyer and R. Lottenberg), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300857.ch21

Editor Information

  1. 1

    Division of Hematology, McMaster University, Hamilton, Ontario, Canada

  2. 2

    St. Joseph's Hospital, Hamilton, Ontario, Canada

  3. 3

    Department of Medicine, McMaster University, Hamilton, Canada

  4. 4

    CLARITY Research Group, Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy

  5. 5

    McMaster University, Hamilton, Canada

  6. 6

    National Cancer Institute of Canada, Clinical Trials Group, Edith Eisenhauer Chair in Clinical Cancer Research, Queen's University, Kingston, Ontario, Canada

  7. 7

    Departments of Oncology and Medicine, Queen's University, Kingston, Ontario, Canada

  8. 8

    Division of Hematology/Oncology, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA

Author Information

  1. 1

    Division of Hematology, McMaster University, Hamilton, Ontario, Canada

  2. 2

    St. Joseph's Hospital, Hamilton, Ontario, Canada

  3. 3

    Department of Medicine, McMaster University, Hamilton, Canada

Publication History

  1. Published Online: 4 FEB 2009
  2. Published Print: 27 JUN 2008

ISBN Information

Print ISBN: 9781405157476

Online ISBN: 9781444300857

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Keywords:

  • antiphospholipid antibody syndrome;
  • anticardiolipin antibodies;
  • anti-β2-glycoprotein I antibodies;
  • optimal management of patients with aPL;
  • antithrombotic recommendations;
  • optimal antithrombotic therapy in patients with antiphospholipid antibodies;
  • optimal management of patients with aPL and arterial thromboembolism;
  • optimal management of women with aPL and pregnancy morbidity

Summary

This chapter contains sections titled:

  • Introduction

  • The clinical questions

  • How are aPL measured in the laboratory?

  • How is APS diagnosed?

  • What is the value of LA, aCL, and anti-β2-GPI assays in the evaluation of patients with suspected APS?

  • What is the optimal management of patients with aPL?

  • What is the optimal management of patients with aPL without thrombosis?

  • What is the optimal management of patients with aPL and venous thromboembolism?

  • What is the optimal management of patients with aPL and arterial thromboembolism?

  • What is the optimal management of patients with aPL and recurrent thrombosis?

  • What is the optimal management of women with aPL and pregnancy morbidity?

  • References