Chapter 22. Clinical Questions in Iron Overload

  1. Mark A. Crowther MD, MSc, FRCPC Professor Division Director3,4,
  2. Jeff Ginsberg MD, FRCPC Professor5,
  3. Holger J. Schünemann MD, PhD, MSc, FACP, FCCP Professor6,7,
  4. Ralph M. Meyer MD, FRCPC Director Professor8,9 and
  5. Richard Lottenberg MD, FACP Professor10
  1. Antonello Pietrangelo MD, PhD1 and
  2. Nicola Magrini MD2

Published Online: 4 FEB 2009

DOI: 10.1002/9781444300857.ch22

Evidence-Based Hematology

Evidence-Based Hematology

How to Cite

Pietrangelo, A. and Magrini, N. (2008) Clinical Questions in Iron Overload, in Evidence-Based Hematology (eds M. A. Crowther, J. Ginsberg, H. J. Schünemann, R. M. Meyer and R. Lottenberg), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444300857.ch22

Editor Information

  1. 3

    Division of Hematology, McMaster University, Hamilton, Ontario, Canada

  2. 4

    St. Joseph's Hospital, Hamilton, Ontario, Canada

  3. 5

    Department of Medicine, McMaster University, Hamilton, Canada

  4. 6

    CLARITY Research Group, Department of Epidemiology, Italian National Cancer Institute Regina Elena, Rome, Italy

  5. 7

    McMaster University, Hamilton, Canada

  6. 8

    National Cancer Institute of Canada, Clinical Trials Group, Edith Eisenhauer Chair in Clinical Cancer Research, Queen's University, Kingston, Ontario, Canada

  7. 9

    Departments of Oncology and Medicine, Queen's University, Kingston, Ontario, Canada

  8. 10

    Division of Hematology/Oncology, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA

Author Information

  1. 1

    Department of Medicine, Center for Hemochromatosis, University of Modena and Reggio Emilia, Modena, Italy

  2. 2

    CeVEAS NHS Centre for the Evaluation of the Effectiveness of Health Care, Modena Local Health Authority, Modena, Italy

Publication History

  1. Published Online: 4 FEB 2009
  2. Published Print: 27 JUN 2008

ISBN Information

Print ISBN: 9781405157476

Online ISBN: 9781444300857



  • benign hematologic disorders;
  • clinical questions in iron overload;
  • disease burden of hereditary hemochromatosis;
  • best diagnostic strategy to identify hereditary hemochromatosis;
  • best treatment strategies for iron overload;
  • marketed iron chelators;
  • transfusion iron loading anemias;
  • effect of phlebotomy on disease progression in biopsy-proven liver fibrosis


This chapter contains sections titled:

  • What is the best noninvasive method to diagnose tissue iron overload?

  • What is the disease burden of hereditary hemochromatosis?

  • What is the best diagnostic strategy to identify hereditary hemochromatosis?

  • What are the best treatment strategies for iron overload?

  • References